NDLI: A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Apostolopoulos, Vasso Plebanski, Magdalena Minigo, Gabriela Katsara, Maria Wright, Mark D. Sofi, Mariam Belz, Gabrielle T. Gartlan, Kate H. Van Spriel, Annemiek B. Tarrant, Jacqueline M. Robb, Lorraine Sheng, Kuo-Ching
Description	Country affiliation: Australia Author Affiliation: Gartlan KH ( Department of Immunology, Monash University, Melbourne, Victoria, Australia.)
Abstract	The cooperative nature of tetraspanin-tetraspanin interactions in membrane organization suggests functional overlap is likely to be important in tetraspanin biology. Previous functional studies of the tetraspanins CD37 and Tssc6 in the immune system found that both CD37 and Tssc6 regulate T cell proliferative responses in vitro. CD37(-/-) mice also displayed a hyper-stimulatory dendritic cell phenotype and dysregulated humoral responses. In this study, we characterize 'double knockout' mice (CD37(-/-)Tssc6(-/-)) generated to investigate functional overlap between these tetraspanins. Strong evidence for a cooperative role for these two proteins was identified in cellular immunity, where both in vitro T cell proliferative responses and dendritic cell stimulation capacity are significantly exaggerated in CD37(-/-)Tssc6(-/-) mice when compared with single knockout counterparts. Despite these exaggerated cellular responses in vitro, CD37(-/-)Tssc6(-/-) mice are not more susceptible to autoimmune induction. However, in vivo responses to pathogens appear poor in CD37(-/-)Tssc6(-/-) mice, which showed a reduced ability to produce influenza-specific T cells and displayed a rapid onset hyper-parasitemia when infected with Plasmodium yoelii. Therefore, in the absence of both CD37 and Tssc6, immune function is further altered when compared with CD37(-/-) or Tssc6(-/-) mice, demonstrating a complementary role for these two molecules in cellular immunity.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	185
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2010-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd Physiology Antigens, Neoplasm Dendritic Cells Immunology Membrane Proteins T-lymphocyte Subsets Amino Acid Sequence Animals Genetics Arthritis, Experimental Pathology Cells, Cultured Metabolism Virology Immunophenotyping Influenza, Human Lymphocyte Activation Malaria Deficiency Mice Mice, Inbred C57bl Mice, Inbred Dba Mice, Knockout Mice, Transgenic Molecular Sequence Data Tetraspanins Comparative Study Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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