NDLI: The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse.

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The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seishima, Mitsuru Ito, Hiroyasu Taguchi, Ayako Saito, Kuniaki Hara, Akira Tanaka, Ryo Ohtaki, Hirofumi Matsunami, Hidetoshi Takemura, Masao Hoshi, Masato Fujigaki, Hidetsugu Osawa, Yosuke
Description	Country affiliation: Japan Author Affiliation: Hoshi M ( Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu City, Gifu Prefecture, Japan.)
Abstract	Indoleamine 2,3-dioxygenase, the L-tryptophan-degrading enzyme, plays a key role in the powerful immunomodulatory effects on several different types of cells. Because modulation of IDO activities after viral infection may have great impact on disease progression, we investigated the role of IDO following infection with LP-BM5 murine leukemia virus. We found suppressed BM5 provirus copies and increased type I IFNs in the spleen from IDO knockout (IDO(-/-)) and 1-methyl-D-L-tryptophan-treated mice compared with those from wild-type (WT) mice. Additionally, the number of plasmacytoid dendritic cells in IDO(-/-) mice was higher in the former than in the WT mice. In addition, neutralization of type I IFNs in IDO(-/-) mice resulted in an increase in LP-BM5 viral replication. Moreover, the survival rate of IDO(-/-) mice or 1-methyl-D-L-tryptophan-treated mice infected with LP-BM5 alone or with both Toxoplasma gondii and LP-BM5 was clearly greater than the survival rate of WT mice. To our knowledge, the present study is the first report to observe suppressed virus replication with upregulated type I IFN in IDO(-/-) mice, suggesting that modulation of the IDO pathway may be an effective strategy for treatment of virus infection.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	185
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2010-09-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Down-regulation Immunology Indoleamine-pyrrole 2,3,-dioxygenase Deficiency Interferon Type I Biosynthesis Leukemia Virus, Murine Retroviridae Infections Enzymology Prevention & Control Up-regulation Virus Replication Adaptive Immunity Genetics Animals Immunity, Innate Physiology Growth & Development Leukemia, Experimental Mice Mice, Inbred C57bl Mice, Knockout Signal Transduction Tumor Virus Infections Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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The absence of IDO upregulates type I IFN production, resulting in suppression of viral replication in the retrovirus-infected mouse.