NDLI: Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models.

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Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models.

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Comment on 'Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways'.

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Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Beckman, Sandra K. Dinh, Hang Chang, Melody W. Cook, Andrew D. Achuthan, Adrian Roiniotis, John Lacey, Derek C. Hamilton, John A. Fleetwood, Andrew J. Scholz, Glen M.
Description	Country affiliation: Australia Author Affiliation: Lacey DC ( Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.)
Abstract	GM-CSF and M-CSF (CSF-1) induce different phenotypic changes in macrophage lineage populations. The nature, extent, and generality of these differences were assessed by comparing the responses to these CSFs, either alone or in combination, in various human and murine macrophage lineage populations. The differences between the respective global gene expression profiles of macrophages, derived from human monocytes by GM-CSF or M-CSF, were compared with the differences between the respective profiles for macrophages, derived from murine bone marrow cells by each CSF. Only 17% of genes regulated differently by these CSFs were common across the species. Whether a particular change in relative gene expression is by direct action of a CSF can be confounded by endogenous mediators, such as type I IFN, IL-10, and activin A. Time-dependent differences in cytokine gene expression were noted in human monocytes treated with the CSFs; in this system, GM-CSF induced a more dramatic expression of IFN-regulated factor 4 (IRF4) than of IRF5, whereas M-CSF induced IRF5 but not IRF4. In the presence of both CSFs, some evidence of 'competition' at the level of gene expression was observed. Care needs to be exercised when drawing definitive conclusions from a particular in vitro system about the roles of GM-CSF and M-CSF in macrophage lineage biology.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	188
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Granulocyte-macrophage Colony-stimulating Factor Physiology Macrophage Colony-stimulating Factor Immunology Macrophages Cytology Animals Cell Lineage Genetics Cells, Cultured Gene Expression Regulation Immunophenotyping Metabolism Mice Mice, Inbred C57bl Mice, Knockout Monocytes Comparative Study Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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