NDLI: A critical role for Rictor in T lymphopoiesis.

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A critical role for Rictor in T lymphopoiesis.

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A critical role for Rictor in T lymphopoiesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, Qi Ikenoue, Tsuneo Zheng, Pan Guan, Kun-Liang Tang, Fei Liu, Yang
Description	Country affiliation: United States Author Affiliation: Tang F ( Division of Immunotherapy, Department of Surgery, University of Michigan Medical School and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA.)
Abstract	Apart from a critical role for Notch and pre-TCR, the signaling pathway required for T lymphopoiesis is largely unknown. Given the potential link between Notch and mammalian target of rapamycin (mTOR) signaling in cancer cells, we used mice with conditional deletion of either Raptor or Rictor genes to determine potential contribution of the mTOR complex I and II in T lymphopoiesis. Our data demonstrated that targeted mutation of Rictor in the thymocytes drastically reduced the thymic cellularity, primarily by reducing proliferation of the immature thymocytes. Rictor deficiency caused a partial block of thymocyte development at the double-negative 3 stage. The effect of Rictor deficiency is selective for the T cell lineage, as the development of B cells, erythrocytes, and myeloid cells is largely unaffected. Analysis of bone marrow chimera generated from a mixture of wild-type and Rictor-deficient hematopoietic stem cells demonstrated that the function of Rictor is cell intrinsic. These data revealed a critical function of mTOR complex 2 in T lymphopoiesis.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201057
Journal	The Journal of Immunology
Issue Number	4
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-08-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carrier Proteins Immunology Cell Differentiation Lymphopoiesis Precursor Cells, T-lymphoid T-lymphocytes Adaptor Proteins, Signal Transducing Animals Metabolism Genetics Flow Cytometry Mice Mice, Inbred C57bl Mice, Transgenic Cytology Real-time Polymerase Chain Reaction Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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