NDLI: Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.

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Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schulze-Osthoff, Klaus Hennel, Roman Herrmann, Martin Ernst, Anne Koppe, Uwe Keppeler, Hildegard Wesselborg, Sebastian Blume, Karin Erika Rosenwald, Matthias Peter, Christoph Belka, Claus Sauer, Guido Lauber, Kirsten
Description	Country affiliation: Germany Author Affiliation: Rosenwald M ( Department of Internal Medicine I, University of Tuebingen, 72076 Tuebingen, Germany.)
Abstract	The elimination of apoptotic cells, called efferocytosis, is fundamentally important for tissue homeostasis and prevents the onset of inflammation and autoimmunity. Serum proteins are known to assist in this complex process. In the current study, we performed a multistep chromatographic fractionation of human serum and identified plasminogen, a protein involved in fibrinolysis, wound healing, and tissue remodeling, as a novel serum-derived factor promoting apoptotic cell removal. Even at levels significantly lower than its serum concentration, purified plasminogen strongly enhanced apoptotic prey cell internalization by macrophages. Plasminogen acted mainly on prey cells, whereas on macrophages no enhancement of the engulfment process was observed. We further demonstrate that the efferocytosis-promoting activity essentially required the proteolytic activation of plasminogen and was completely abrogated by the urokinase plasminogen activator inhibitor-1 and serine protease inhibitor aprotinin. Thus, our study assigns a new function to plasminogen and plasmin in apoptotic cell clearance.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	12
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Regulatory Proteins Physiology Apoptosis Immunology Phagocytosis Plasminogen Metabolism Abo Blood-group System Blood Cell Line, Tumor Chromatography, Affinity Macrophages Cytology Deficiency Primary Cell Culture Serum Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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The urokinase plasminogen activator receptor promotes efferocytosis of apoptotic cells.

Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.

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Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance.