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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Strugnell, Richard A. Brooks, Andrew G. Smyth, Mark J. Curtiss, Roy Belz, Gabrielle T. Greyer, Marie Lew, Andrew M. Andrews, Daniel M. Kupz, Andreas Scott, Timothy A. Bedoui, Sammy |
| Description | Author Affiliation: Kupz A ( Department of Microbiology and Immunology, University of Melbourne, Parkville, 3010 VIC, Australia.); |
| Abstract | IFN-γ is critical for immunity against infections with intracellular pathogens, such as Salmonella enterica. However, which of the many cell types capable of producing IFN-γ controls Salmonella infections remains unclear. Using a mouse model of systemic Salmonella infection, we observed that only a lack of all lymphocytes or CD90 (Thy1)(+) cells, but not the absence of T cells, Retinoic acid-related orphan receptor (ROR)-γt-dependent lymphocytes, (NK)1.1(+) cells, natural killer T (NKT), and/or B cells alone, replicated the highly susceptible phenotype of IFN-γ-deficient mice to Salmonella infection. A combination of antibody depletions and adoptive transfer experiments revealed that early protective IFN-γ was provided by Thy1-expressing natural killer (NK) cells and that these cells improved antibacterial immunity through the provision of IFN-γ. Further analysis of NK cells producing IFN-γ in response to Salmonella indicated that less mature NK cells were more efficient at mediating antibacterial effector function than terminally differentiated NK cells. Inspired by recent reports of Thy1(+) NK cells contributing to immune memory, we analyzed their role in secondary protection against otherwise lethal WT Salmonella infections. Notably, we observed that a newly generated Salmonella vaccine strain not only conferred superior protection compared with conventional regimens but that this enhanced efficiency of recall immunity was afforded by incorporating CD4(-)CD8(-)Thy1(+) cells into the secondary response. Taken together, these findings demonstrate that Thy1-expressing NK cells play an important role in antibacterial immunity. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 110 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2013-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Interferon-gamma Biosynthesis Killer Cells, Natural Immunology Microbiology Salmonella Infections, Animal Salmonella Typhimurium Adoptive Transfer Animals Antigens, Thy-1 Metabolism Cell Differentiation DNA-Binding Proteins Deficiency Genetics Homeodomain Proteins Classification Pathology Lymphocyte Subsets Mice Mice, Inbred C57BL Mice, Knockout Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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