NDLI: HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile.

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HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	David, Chella S. Mangalam, Ashutosh K. Taneja, Veena
Description	Country affiliation: United States Author Affiliation: Mangalam AK ( Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. mangalam.ashutosh@mayo.edu)
Abstract	The MHC in humans encodes the most polymorphic genes, the HLA genes, which are critical for the immune system to clear infection. This can be attributed to strong selection pressure as populations moved to different parts of the world and encountered new kinds of infections, leading to new HLA class II alleles. HLA genes also have the highest relative risk for autoimmune diseases. Three haplotypes, that is, HLA-DR2DQ6, DR4DQ8, and DR3DQ2, account for HLA association with most autoimmune diseases. We hypothesize that these haplotypes, along with their multiple subtypes, have survived bottlenecks of infectious episodes in human history because of their ability to present pathogenic peptides to activate T cells that secrete cytokines to clear infections. Unfortunately, they also present self-peptides/mimics to activate autoreactive T cells secreting proinflammatory cytokines that cause autoimmune diseases.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201891
Journal	The Journal of Immunology
Issue Number	2
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-01-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoimmune Diseases Genetics Immunology Cytokines Metabolism Disease Susceptibility Hla-d Antigens Animals Prevention & Control Autoimmunity Cd4-positive T-lymphocytes Haplotypes T-lymphocyte Subsets Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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