NDLI: Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.

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Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hou, Lifei Soong, Lynn Desai, Mayura Liang, Yuejin Jie, Zuliang Sun, Jiaren Wang, Tian
Description	Country affiliation: United States Author Affiliation: Hou L ( Department of Microbiology and Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.)
Abstract	This study was conducted to examine the interactions among the innate and adaptive immune components of the liver parenchyma during acute viral hepatitis. Mice were i.v. infected with a recombinant adenovirus, and within the first 24 h of infection, we found a transient but significant accumulation of IL-17 and IL-23 in the liver. In vivo neutralization of these interleukins alleviated the liver injury. Further investigations showed that IL-17 neutralization halted the intrahepatic accumulation of CTLs and Th1 cells. A majority of the IL-17-producing cells in the liver were Î³Î´ T cells. Additionally, intrahepatic IL-17(+) Î³Î´ T cells, but not the IFN-Î³(+) ones, preferentially expressed IL-7R (CD127) on their surface, which coincided with an elevation of hepatocyte-derived IL-7 at 12 h postinfection. IL-7R blockade in vivo severely impeded the expansion of IL-17-producing cells after viral infection. In vitro, IL-7 synergized with IL-23 and directly stimulated IL-17 production from Î³Î´ T cells in response to TCRÎ³Î´ stimulation. Finally, type I IFN (IFN-I) signaling was found to be critical for hepatic IL-7 induction. Collectively, these results showed that the IFN-I/IL-7/IL-17 cascade was important in priming T cell responses in the liver. Moreover, the highly coordinated cross talk among hepatocytes and innate and adaptive immune cells played a critical role in anti-viral immunity in hepatitis.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201970
Journal	The Journal of Immunology
Issue Number	2
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-01-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adaptive Immunity Hepatitis, Viral, Animal Immunology Metabolism Interleukin-17 Biosynthesis Liver T-lymphocytes Animals Pathology Hepatocytes Interferon Type I Interleukin-23 Interleukin-7 Mice Mice, Knockout Receptors, Antigen, T-cell, Gamma-delta Signal Transduction T-lymphocyte Subsets Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.

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Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.