NDLI: Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.

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Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Busche, Andreas Jirmo, Adan Chari Constabel, Hannelore Noack, Julia Behrens, Georg M. N. Gatzke, Anna-Katherina Welten, Suzanne P. M. Arens, Ramon Messerle, Martin Keyser, Kirsten A. Zischke, Jasmin
Description	Country affiliation: Germany Author Affiliation: Busche A ( Department of Virology, Hannover Medical School, 30625 Hannover, Germany.)
Abstract	CMV can infect dendritic cells (DCs), and direct Ag presentation could, therefore, lead to the priming of CMV-specific CD8(+) T cells. However, CMV-encoded immune evasins severely impair Ag presentation in the MHC class I pathway; thus, it is widely assumed that cross-presentation drives the priming of antiviral T cells. We assessed the contribution of direct versus cross priming in mouse CMV (MCMV) infection using recombinant viruses. DCs infected with an MCMV strain encoding the gB498 epitope from HSV-1 were unable to stimulate in vitro naive gB498-specific CD8(+) T cells from TCR transgenic mice. Infection of C57BL/6 mice with this recombinant virus led, however, to the generation of abundant numbers of gB498-specific T cells in vivo. Of the DC subsets isolated from infected mice, only CD8 (+) DCs were able to stimulate naive T cells, suggesting that this DC subset cross-presents MCMV-encoded Ag in vivo. Upon infection of mice with MCMV mutants encoding Ag that can either be well or hardly cross-presented, mainly CD8(+) T cells specific for cross-presented epitopes were generated. Moreover, even in the absence of immune evasion genes interfering with MHC class I-mediated Ag presentation, priming of T cells to Ag that can only be presented directly was not observed. We conclude that the host uses mainly DCs capable of cross-presentation to induce the CMV-specific CD8(+) T cell response during primary, acute infection and discuss the implications for the development of a CMV vaccine.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	6
Volume Number	190
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-03-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Viral Immunology Cd8-positive T-lymphocytes Virology Cross-priming Herpesviridae Infections Lymphocyte Activation Muromegalovirus Animals Antigen-presenting Cells Pathology Clone Cells Epitopes, T-lymphocyte Mice Mice, Inbred C57bl Mice, Transgenic Genetics Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation.

Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.

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Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization.

CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells.

Î³-Herpesvirus reactivation differentially stimulates epitope-specific CD8 T cell responses.

Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.

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Prolonged antigen presentation following an acute virus infection requires direct and then cross-presentation.

Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.

Modification of a tumor antigen determinant to improve peptide/MHC stability is associated with increased immunogenicity and cross-priming a larger fraction of CD8+ T cells.

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Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation.