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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kochanek, Stefan Bernhard, Caroline A. Ried, Christine Brocker, Thomas |
| Description | Author Affiliation: Bernhard CA ( Institute for Immunology, Ludwig-Maximilian University of Munich, 80336 Munich, Germany and.); Ried C ( Institute for Immunology, Ludwig-Maximilian University of Munich, 80336 Munich, Germany and.); Kochanek S ( Department of Gene Therapy, University of Ulm, 89081 Ulm, Germany.); Brocker T ( Institute for Immunology, Ludwig-Maximilian University of Munich, 80336 Munich, Germany and tbrocker@med.uni-muenchen.de.); |
| Abstract | Dendritic cells (DCs) are considered the most potent antigen-presenting cells (APCs), which directly prime or cross-prime MHC I-restricted cytotoxic T cells (CTLs). However, recent evidence suggests the existence of other, as-yet unidentified APCs also able to prime T cells. To identify those APCs, we used adenoviral (rAd) vectors, which do not infect DCs but selectively accumulate in CD169(+) macrophages (MPs). In mice that lack DCs, infection of CD169(+) MPs was sufficient to prime CTLs specific for all epitopes tested. In contrast, CTL responses relying exclusively on cross-presenting DCs were biased to selected strong MHC I-binding peptides only. When both DCs and MPs were absent, no CTL responses could be elicited. Therefore, CD169(+) MPs can be considered APCs that significantly contribute to CTL responses. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 112 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2015-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigen Presentation Physiology Antigens, CD Immunology Antigens, Differentiation, T-Lymphocyte CD8-Positive T-Lymphocytes Dendritic Cells Epitopes, T-Lymphocyte Lectins, C-Type Animals Cytology Cross Reactions Mice Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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