NDLI: Important role for FcÎ³RIIB on B lymphocytes for mucosal antigen-induced tolerance and Foxp3+ regulatory T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Holmgren, Jan Xiang, Zou Smith, Kenneth G. C. Sun, Jia-Bin
Description	Author Affiliation: Sun JB ( University of Gothenburg Vaccine Institute, SE405 30 Göteborg, Sweden)
Abstract	FcÎ³RIIB, the only FcÎ³R expressed on B cells, is important in the maintenance of immunological tolerance to self-Ags. In this study, we investigated the role of FcÎ³RIIB in Ag-specific CD4 T cell tolerance induced by mucosally administered Ag (OVA) coupled to cholera toxin B subunit (Ag/CTB) or given alone. We found that sublingual administration of Ag/CTB conjugate or intragastric administration of a >100-fold higher dose of Ag alone efficiently suppressed parenteral immunization-induced Ag-specific T cell proliferation and delayed-type hypersensitivity responses in FcÎ³RIIB-expressing wild-type (WT), but not FcÎ³RIIB(-/-), mice. Such mucosally induced tolerance (oral tolerance) associated with induction of Ag-specific Foxp3(+) regulatory T cells was restored in FcÎ³RIIB(-/-) mice by adoptive transfer of either WT B cells or WT dendritic cells before the mucosal Ag/CTB treatment; it was even more pronounced in µMT mice that received FcÎ³RIIB-overexpressing B cells before treatment. Furthermore, cell transfer in either WT or µMT mice of WT but not FcÎ³RIIB(-/-) B cells pretreated for 1 h in vitro with Ag/CTB conjugate induced Ag-specific immunological tolerance, which was further enhanced by adoptive transfer of WT B cells pretreated with anti-Ag IgG immune complexed Ag/CTB. We conclude that FcÎ³RIIB expression on B cells, in addition to dendritic cells, is important for mucosal induction of Ag-specific immune tolerance.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	8
Volume Number	191
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-10-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-lymphocytes Immunology Dendritic Cells Immune Tolerance Receptors, Igg T-lymphocytes, Regulatory Adoptive Transfer Animals Autoantigens Transplantation Cell Proliferation Cells, Cultured Cholera Toxin Forkhead Transcription Factors Metabolism Hypersensitivity, Delayed Mice Mice, Inbred C57bl Mice, Knockout Ovalbumin Deficiency Genetics Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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