NDLI: IL-17 promotes neutrophil entry into tumor-draining lymph nodes following induction of sterile inflammation.

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IL-17 promotes neutrophil entry into tumor-draining lymph nodes following induction of sterile inflammation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Muhitch, Jason B. Gollnick, Sandra O. Evans, Sharon S. Brackett, Craig M.
Description	Author Affiliation: Brackett CM ( Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263.)
Abstract	Blood-borne neutrophils are excluded from entering lymph nodes across vascular portals termed high endothelial venules (HEVs) because of lack of expression of the CCR7 homeostatic chemokine receptor. Induction of sterile inflammation increases neutrophil entry into tumor-draining lymph nodes (TDLNs), which is critical for induction of antitumor adaptive immunity following treatments such as photodynamic therapy (PDT). However, the mechanisms controlling neutrophil entry into TDLNs remain unclear. Prior evidence that IL-17 promotes neutrophil emigration to sites of infection via induction of CXCL2 and CXCL1 inflammatory chemokines raised the question of whether IL-17 contributes to chemokine-dependent trafficking in TDLNs. In this article, we demonstrate rapid accumulation of IL-17-producing Th17 cells in the TDLNs following induction of sterile inflammation by PDT. We further report that nonhematopoietic expression of IL-17RA regulates neutrophil accumulation in TDLNs following induction of sterile inflammation by PDT. We show that HEVs are the major route of entry of blood-borne neutrophils into TDLNs through interactions of l-selectin with HEV-expressed peripheral lymph node addressin and by preferential interactions between CXCR2 and CXCL2 but not CXCL1. CXCL2 induction in TDLNs was mapped in a linear pathway downstream of IL-17RA-dependent induction of IL-1ß. These results define a novel IL-17-dependent mechanism promoting neutrophil delivery across HEVs in TDLNs during acute inflammatory responses.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1103621
Journal	The Journal of Immunology
Issue Number	8
Volume Number	191
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2013-10-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Inflammation Immunology Interleukin-17 Metabolism Lymph Nodes Neoplasms Neutrophils Animals Cell Movement Chemokine Cxcl1 Chemokine Cxcl2 Biosynthesis Interleukin-1beta L-selectin Cytology Mice Mice, Inbred Balb C Mice, Knockout Photochemotherapy Receptors, Interleukin-17 Receptors, Interleukin-8b Th17 Cells Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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