NDLI: Functional NK cell repertoires are maintained through IL-2R and Fas ligand.

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Functional NK cell repertoires are maintained through IL-2R and Fas ligand.

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Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells.

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Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.

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Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma

The Drosophila imd signaling pathway.

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Functional NK cell repertoires are maintained through IL-2R and Fas ligand.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miller, Jeffrey S. Ankarlo, Dave E. M. Luo, Xianghua Curtsinger, Julie Lenvik, Todd R. Anderson, Stephen K. Blazar, Bruce R. Foley, Bree Felices, Martin
Description	Author Affiliation: Felices M ( Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455)
Abstract	Acquisition of a functional NK cell repertoire, known as education or licensing, is a complex process mediated through inhibitory receptors that recognize self. We found that NK cells containing self-killer Ig-like receptors for cognate HLA ligand in vivo were less susceptible to apoptosis. In vitro IL-15 withdrawal showed that uneducated NK cells upregulated Bim and Fas. Conversely, educated NK cells upregulated Fas ligand (FasL) under these conditions. Induction of cell death and Bim expression on uneducated cells correlated with increased IL-2R expression. Overexpression and knockdown studies showed that higher IL-2R limits NK cell survival in a novel manner that is independent from the role of IL-2 in activation-induced cell death. To study the role of FasL in induction of IL-2R (hi) NK cell death, a coculture assay with FasL-blocking Abs was used. IL-15 withdrawal led to FasL-dependent killing of IL-2R (hi) NK cells by more educated IL-2R (lo) NK cells. Finally, CMV reactivation induces a potent long-lasting population of licensed NK cells with enhanced survival. These findings show that education-dependent NK cell survival advantages and killing of uneducated NK cells result in the maintenance of a functional repertoire, which may be manipulated to exploit NK cells for cancer immunotherapy.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1302601
Journal	The Journal of Immunology
Issue Number	8
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-04-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Fas Ligand Protein Metabolism Interleukin-2 Receptor Alpha Subunit Killer Cells, Natural Animals Apoptosis Genetics Immunology Apoptosis Regulatory Proteins Cell Communication Cell Differentiation Cell Proliferation Cell Survival Drug Effects Cytomegalovirus Physiology Gene Expression Regulation Homeostasis Interleukin-15 Pharmacology Cytology Membrane Proteins Mice Mice, Knockout Proto-oncogene Proteins Receptors, Cytokine Receptors, Kir Virus Activation Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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