NDLI: Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.

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Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.

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Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Martin, Matthew D. Duong, Sean Condotta, Stephanie A. Rai, Deepa Griffith, Thomas S. Badovinac, Vladimir P.
Description	Author Affiliation: Duong S ( Department of Pathology, University of Iowa, Iowa City, IA 52242)
Abstract	Mortality from sepsis frequently results from secondary infections, and the extent to which sepsis affects pathogen-specific memory CD8 T cell responses remains unknown. Using the cecal ligation and puncture model of polymicrobial sepsis, we observed rapid apoptosis of pre-existing memory CD8 T cells after sepsis induction that led to a loss in CD8 T cell-mediated protection. Ag sensitivity (functional avidity) and Ag-driven secondary expansion of memory CD8 T cells were decreased after sepsis, further contributing to the observed loss in CD8 T cell-mediated immunity. Moreover, Ag-independent bystander activation of memory CD8 T cells in response to heterologous infection was also significantly impaired early after sepsis induction. The reduced sensitivity of pre-existing memory CD8 T cells to sense inflammation and respond to heterologous infection by IFN-Î³ production was observed in inbred and outbred hosts and controlled by extrinsic (but not cell-intrinsic) factors, suggesting that sepsis-induced changes in the environment regulate innate functions of memory CD8 T cells. Taken together, the data in this study revealed a previously unappreciated role of sepsis in shaping the quantity and functionality of infection- or vaccine-induced memory CD8 T cells and will help further define the decline in T cell-mediated immunity during the sepsis-induced phase of immunosuppression.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1303460
Journal	The Journal of Immunology
Issue Number	8
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-04-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens Immunology Cd8-positive T-lymphocytes Immunologic Memory Sepsis Animals Metabolism Disease Models, Animal Immunity, Innate Immunosuppression Interferon-gamma Biosynthesis Lymphocyte Activation Lymphocyte Count Mice Receptors, Antigen, T-cell Blood Microbiology Virology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s. Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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