NDLI: Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells.

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Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eberl, Matthias Szakmany, Tamas Davey, Martin S. Moser, Bernhard Morgan, Matt P. Liuzzi, Anna Rita Hall, Judith E. Khan, Mohd Wajid A. Tyler, Christopher J.
Description	Author Affiliation: Davey MS ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Morgan MP ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Liuzzi AR ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Tyler CJ ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Khan MW ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Szakmany T ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Hall JE ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Moser B ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom); Eberl M ( Cardiff Institute of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom)
Abstract	The early immune response to microbes is dominated by the recruitment of neutrophils whose primary function is to clear invading pathogens. However, there is emerging evidence that neutrophils play additional effector and regulatory roles. The present study demonstrates that human neutrophils assume Ag cross-presenting functions and suggests a plausible scenario for the local generation of APC-like neutrophils through the mobilization of unconventional T cells in response to microbial metabolites. VÎ³9/VÎ´2 T cells and mucosal-associated invariant T cells are abundant in blood, inflamed tissues, and mucosal barriers. In this study, both human cell types responded rapidly to neutrophils after phagocytosis of Gram-positive and Gram-negative bacteria producing the corresponding ligands, and in turn mediated the differentiation of neutrophils into APCs for both CD4(+) and CD8(+) T cells through secretion of GM-CSF, IFN-Î³, and TNF- . In patients with acute sepsis, circulating neutrophils displayed a similar APC-like phenotype and readily processed soluble proteins for cross-presentation of antigenic peptides to CD8(+) T cells, at a time when peripheral VÎ³9/VÎ´2 T cells were highly activated. Our findings indicate that unconventional T cells represent key controllers of neutrophil-driven innate and adaptive responses to a broad range of pathogens.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1401018
Journal	The Journal of Immunology
Issue Number	7
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigen Presentation Cd4-positive T-lymphocytes Immunology Cd8-positive T-lymphocytes Cell Differentiation Cross-priming Gram-negative Bacteria Gram-positive Bacteria Adaptive Immunity Pathology Immunity, Innate Neutrophils Receptors, Antigen, T-cell, Gamma-delta Clinical Trial Multicenter Study Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Microbe-specific unconventional T-cells induce human neutrophil differentiation into antigen cross-presenting cells

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Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells.

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