NDLI: Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 193 Issue: 12

Year: 2014 Volume: 193 Issue: 11

Year: 2014 Volume: 193 Issue: 10

Year: 2014 Volume: 193 Issue: 9

Year: 2014 Volume: 193 Issue: 8

Year: 2014 Volume: 193 Issue: 7

Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice.

The survival and differentiation of pro-B and pre-B cells in the bone marrow is dependent on IL-7R Tyr449.

Fungal ß-glucan, a Dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response.

IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2.

The effects of 1,25-dihydroxyvitamin D3 on in vitro human NK cell development from hematopoietic stem cells.

Complement component C5a permits the coexistence of pathogenic Th17 cells and type I IFN in lupus.

Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells.

Contribution of TCR signaling strength to CD8+ T cell peripheral tolerance mechanisms.

Characterization of cross-protection by genetically modified live-attenuated Leishmania donovani parasites against Leishmania mexicana.

Axl receptor blockade protects from invasive pulmonary aspergillosis in mice.

Differential control of Mincle-dependent cord factor recognition and macrophage responses by the transcription factors C/EBPß and HIF1 .

Basophils promote innate lymphoid cell responses in inflamed skin.

Inhibition of TYK2 and JAK1 ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting IL-22 and the IL-23/IL-17 axis.

TGF-ß-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells.

HIV-1 and HIV-2 differentially mature plasmacytoid dendritic cells into IFN-producing cells or APCs.

The cross-priming capacity and direct presentation potential of an autoantigen are separable and inversely related properties.

Plasmin induces in vivo monocyte recruitment through protease-activated receptor-1-, MEK/ERK-, and CCR2-mediated signaling.

Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells.

The mouse idd2 locus is linked to the proportion of immunoregulatory double-negative T cells, a trait associated with autoimmune diabetes resistance.

Notch signaling at later stages of NK cell development enhances KIR expression and functional maturation.

Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts.

Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.

Transcriptional characterization of the T cell population within the salmonid interbranchial lymphoid tissue.

The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation.

Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells.

Helicobacter pylori-induced IL-1ß secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island.

TLR-mediated inflammatory responses to Streptococcus pneumoniae are highly dependent on surface expression of bacterial lipoproteins.

IL-21 is a central memory T cell-associated cytokine that inhibits the generation of pathogenic Th1/17 effector cells.

Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.

CXCL1 contributes to host defense in polymicrobial sepsis via modulating T cell and neutrophil functions.

Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis.

Immunoregulation of dendritic cells by the receptor T cell Ig and mucin protein-3 via Bruton's tyrosine kinase and c-Src.

GATA-3 dose-dependent checkpoints in early T cell commitment.

Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury.

CD39 and CD161 modulate Th17 responses in Crohn's disease.

Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults.

T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils.

Macrophage migration inhibitory factor triggers chemotaxis of CD74+CXCR2+ NKT cells in chemically induced IFN-Î³-mediated skin inflammation.

CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.

Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-Î³ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.

Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product.

A major deletion in the Vκ-Jκ intervening region results in hyperelevated transcription of proximal Vκ genes and a severely restricted repertoire.

C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection.

Endothelial microparticles interact with and support the proliferation of T cells.

Crucial role of macrophage selenoproteins in experimental colitis.

Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents.

Systemic C3 modulates CD8+ T cell contraction after Listeria monocytogenes infection.

The UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms

Monocyte-induced development of Th17 cells and the release of S100 proteins are involved in the pathogenesis of graft-versus-host disease.

Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly.

STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis.

SHP-1 plays a crucial role in CD40 signaling reciprocity.

TLR9 transcriptional regulation in response to double-stranded DNA viruses.

Pegylated bisacycloxypropylcysteine, a diacylated lipopeptide ligand of TLR6, plays a host-protective role against experimental Leishmania major infection.

Comment on 'differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors'.

Macrophage activation as an effector mechanism for cell-mediated immunity.

Helminth infections decrease host susceptibility to immune-mediated diseases.

Putting J chain back on the map: how might its expression define plasma cell development?

Year: 2014 Volume: 193 Issue: 6

Year: 2014 Volume: 193 Issue: 5

Year: 2014 Volume: 193 Issue: 4

Year: 2014 Volume: 193 Issue: 3

Year: 2014 Volume: 193 Issue: 2

Year: 2014 Volume: 193 Issue: 1

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Novel CD8 T cell alloreactivities in CCR5-deficient recipients of class II MHC disparate kidney grafts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ishii, Daisuke Baldwin, William M. Nozaki, Taiji Rosenblum, Joshua M. Setoguchi, Kiyoshi Schenk, Austin D. Su, Charles A. Gorbacheva, Victoria Valujskikh, Anna Fairchild, Robert L.
Description	Author Affiliation: Ishii D ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Rosenblum JM ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Nozaki T ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Schenk AD ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Setoguchi K ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Su CA ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Gorbacheva V ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Baldwin WM ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Valujskikh A ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195); Fairchild RL ( Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195)
Abstract	Recipient CD4 T regulatory cells inhibit the acute T cell-mediated rejection of renal allografts in wild-type mice. The survival of single class II MHC-disparate H-2(bm12) renal allografts was tested in B6.CCR5(-/-) recipients, which have defects in T regulatory cell activities that constrain alloimmune responses. In contrast to wild-type C57BL/6 recipients, B6.CCR5(-/-) recipients rejected the bm12 renal allografts. However, donor-reactive CD8 T cells rather than CD4 T cells were the primary effector T cells mediating rejection. The CD8 T cells induced to bm12 allografts in CCR5-deficient recipients were reactive to peptides spanning the 3 aa difference in the I-A(bm12) versus I-A(b) ß-chains presented by K(b) and D(b) class I MHC molecules. Allograft-primed CD8 T cells from CCR5-deficient allograft recipients were activated during culture either with proinflammatory cytokine-stimulated wild-type endothelial cells pulsed with the I-A(bm12) peptides or with proinflammatory cytokine-simulated bm12 endothelial cells, indicating their presentation of the I-A(bm12) ß-chain peptide/class I MHC complexes. In addition to induction by bm12 renal allografts, the I-A(bm12) ß-chain-reactive CD8 T cells were induced in CCR5-deficient, but not wild-type C57BL/6, mice by immunization with the peptides. These results reveal novel alloreactive CD8 T cell specificities in CCR5-deficient recipients of single class II MHC renal allografts that mediate rejection of the allografts.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1303256
Journal	The Journal of Immunology
Issue Number	7
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Graft Rejection Histocompatibility Antigens Class Ii Kidney Transplantation Receptors, Ccr5 Allografts Animals Pathology Cytokines Genetics H-2 Antigens Mice Mice, Knockout Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in