NDLI: CCAAT/enhancer-binding protein negatively regulates IFN-Î³ expression in T cells.

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CCAAT/enhancer-binding protein negatively regulates IFN-Î³ expression in T cells.

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CCAAT/enhancer-binding protein negatively regulates IFN-Î³ expression in T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Magnusson, Fay Martinez, Gustavo J. Wang, Yi-hong Chung, Yeonseok Tanaka, Shinya Tanaka, Kentaro Nurieva, Roza I. Kurosaki, Tomohiro Dong, Chen
Description	Author Affiliation: Tanaka S ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054); Tanaka K ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054); Magnusson F ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054); Chung Y ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054); Martinez GJ ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054); Wang YH ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054); Nurieva RI ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054); Kurosaki T ( Laboratory of Lymphocyte Differentiation, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan); Dong C ( Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054)
Abstract	Humoral immunity, including Ab switching and somatic hypermutation, is critically regulated by CD4(+) T cells. T follicular helper (Tfh) cells have been recently shown to be a distinct T cell subset important in germinal center reactions. The transcriptional regulation of Tfh cell development and function has not been well understood. In this study, we report that C/EBP , a basic region/leucine zipper transcription factor, is highly expressed in Tfh cells. Cebpa-deficient CD4(+) T cells exhibit enhanced IFN-Î³ expression in vitro and in vivo. T cell-specific Cebpa knockout mice, although not defective in Tfh cell generation, produce significantly increased levels of IgG2a/b and IgG3 following immunization with a protein Ag. Moreover, C/EBP binds to the Ifng gene and inhibits T-bet-driven Ifng transcription in a DNA binding-dependent manner. Our study thus demonstrates that C/EBP restricts IFN-Î³ expression in T cells to allow proper class switching by B cells.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1303422
Journal	The Journal of Immunology
Issue Number	12
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ccaat-enhancer-binding Protein-alpha Metabolism Gene Expression Regulation Interferon-gamma Genetics T-lymphocyte Subsets Animals B-lymphocytes Immunology Deficiency Cell Differentiation Gene Expression Profiling Immunity, Humoral Immunoglobulin Class Switching Immunoglobulin G Mice Mice, Knockout T-box Domain Proteins Cytology T-lymphocytes, Helper-inducer Transcription, Genetic Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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