NDLI: Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production

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Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production

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Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Paquette, Jackie K. Weis, Janis J. Teuscher, Cory Lochhead, Robert B. Ma, Ying Zachary, James F. Weis, John H. Bramwell, Kenneth K. C.
Description	Author Affiliation: Ma Y ( Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112); Bramwell KK ( Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112); Lochhead RB ( Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112); Paquette JK ( Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112); Zachary JF ( Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802); Weis JH ( Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112); Teuscher C ( Department of Medicine, University of Vermont, Burlington, VT 05405.); Weis JJ ( Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT 84112)
Abstract	Localized upregulation of type I IFN was previously implicated in development of Borrelia burgdorferi-induced arthritis in C3H mice, and was remarkable due to its absence in the mildly arthritic C57BL/6 (B6) mice. Independently, forward genetics analysis identified a quantitative trait locus on Chr4, termed B. burgdorferi-associated locus 1 (Bbaa1), that regulates Lyme arthritis severity and includes the 15 type I IFN genes. Involvement of Bbaa1 in arthritis development was confirmed in B6 mice congenic for the C3H allele of Bbaa1 (B6.C3-Bbaa1), which developed more severe Lyme arthritis and K/B×N model of rheumatoid arthritis (RA) than did parental B6 mice. Administration of a type I IFN receptor blocking mAb reduced the severity of both Lyme arthritis and RA in B6.C3-Bbaa1 mice, formally linking genetic elements within Bbaa1 to pathological production of type I IFN. Bone marrow-derived macrophages from Bbaa1 congenic mice implicated this locus as a regulator of type I IFN induction and downstream target gene expression. Bbaa1-mediated regulation of IFN-inducible genes was upstream of IFN receptor-dependent amplification; however, the overall magnitude of the response was dependent on autocrine/paracrine responses to IFN-ß. In addition, the Bbaa1 locus modulated the functional phenotype ascribed to bone marrow-derived macrophages: the B6 allele promoted expression of M2 markers, whereas the C3H allele promoted induction of M1 responses. This report identifies a genetic locus physically and functionally linked to type I IFN that contributes to the pathogenesis of both Lyme and RA.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1401746
Journal	The Journal of Immunology
Issue Number	12
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Arthritis, Rheumatoid Genetics Metabolism Borrelia Burgdorferi Immunology Interferon Type I Lyme Disease Quantitative Trait Loci Alleles Animals Disease Models, Animal Gene Expression Regulation Drug Effects Interferon Regulatory Factors Pharmacology Macrophages Mice Mice, Inbred C3h Mice, Inbred C57bl Mice, Knockout Phagocytosis Phenotype Receptor, Interferon Alpha-beta Antagonists & Inhibitors Transcriptional Activation Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production

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Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production

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Borrelia burgdorferi arthritis associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of Type I IFN production