| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Lanzer, Kathleen G. Jensen, Meghan K. Huston, Gail E. Peters, Bjoern Woodland, David L. Blackman, Marcia A. Burkum, Claire E. Sette, Alessandro Roberts, Alan D. Van Dyk, Linda F. Sidney, John Cookenham, Tres Freeman, Michael L. Kohlmeier, Jacob E. |
| Description |
Author Affiliation: Freeman ML ( Trudeau Institute, Saranac Lake, NY 12983); Burkum CE ( Trudeau Institute, Saranac Lake, NY 12983); Cookenham T ( Trudeau Institute, Saranac Lake, NY 12983); Roberts AD ( Trudeau Institute, Saranac Lake, NY 12983); Lanzer KG ( Trudeau Institute, Saranac Lake, NY 12983); Huston GE ( Trudeau Institute, Saranac Lake, NY 12983); Jensen MK ( Trudeau Institute, Saranac Lake, NY 12983); Sidney J ( Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037); Peters B ( Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037); Kohlmeier JE ( Trudeau Institute, Saranac Lake, NY 12983); Woodland DL ( Trudeau Institute, Saranac Lake, NY 12983); van Dyk LF ( Department of Microbiology, University of Colorado School of Medicine, Aurora, CO 80045); Sette A ( Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037); Blackman MA ( Trudeau Institute, Saranac Lake, NY 12983) |
| Abstract |
The oncogenic γ-herpesviruses EBV and Kaposi sarcoma-associated herpesvirus are ubiquitous human pathogens that establish lifelong latent infections maintained by intermittent viral reactivation and reinfection. Effector CD4 T cells are critical for control of viral latency and in immune therapies for virus-associated tumors. In this study, we exploited γHV68 infection of mice to enhance our understanding of the CD4 T cell response during γ-herpesvirus infection. Using a consensus prediction approach, we identified 16 new CD4 epitope-specific responses that arise during lytic infection. An additional epitope encoded by the M2 protein induced uniquely latency-associated CD4 T cells, which were not detected at the peak of lytic infection but only during latency and were not induced postinfection with a latency-deficient virus. M2-specific CD4 T cells were selectively cytotoxic, produced multiple antiviral cytokines, and sustained IL-2 production. Identification of latency-associated cytolytic CD4 T cells will aid in dissecting mechanisms of CD4 immune control of γ-herpesvirus latency and the development of therapeutic approaches to control viral reactivation and pathology. |
| ISSN |
00221767 |
| e-ISSN |
15506606 |
| DOI |
10.4049/jimmunol.1302060 |
| Journal |
The Journal of Immunology |
| Issue Number |
12 |
| Volume Number |
193 |
| Language |
English |
| Publisher |
The American Association of Immunologists |
| Publisher Date |
2014-12-15 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Cd4-positive T-lymphocytes Immunology Cytotoxicity, Immunologic Epitopes, T-lymphocyte Gammaherpesvirinae Virus Latency Amino Acid Sequence Animals Metabolism Cytokines Biosynthesis Chemistry Herpesviridae Infections Virology Interferon-gamma Lymphocyte Activation Mice Molecular Sequence Data Peptides T-cell Antigen Receptor Specificity Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Immunology and Allergy Immunology |
