NDLI: The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eguizabal, Cristina Simhadri, Venkateswara R. Vitallé, Joana Zenarruzabeitia, Olatz Borrego, Francisco
Description	Author Affiliation: Zenarruzabeitia O ( Immunopathology Group, BioCruces Health Research Institute, Barakaldo 48903, Spain); Vitallé J ( Immunopathology Group, BioCruces Health Research Institute, Barakaldo 48903, Spain); Eguizabal C ( Cell Therapy and Stem Cell Group, Basque Center for Transfusion and Human Tissues, Galdakao 48960, Spain); Simhadri VR ( Division of Biotechnology Review and Research-I, Office of Biotechnology Products Review and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993); Borrego F ( Immunopathology Group, BioCruces Health Research Institute, Barakaldo 48903, Spain)
Abstract	The CD300a inhibitory receptor belongs to the CD300 family of cell surface molecules that regulate a diverse array of immune cell processes. The inhibitory signal of CD300a depends on the phosphorylation of tyrosine residues embedded in ITIMs of the cytoplasmic tail. CD300a is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type. The finding that CD300a recognizes phosphatidylserine and phosphatidylethanolamine, two aminophospholipids exposed on the outer leaflet of dead and activated cells, has shed new light on its role in the modulation of immune functions and in its participation in the host response to several diseases states, such as infectious diseases, cancer, allergy, and chronic inflammatory diseases. This review summarizes the literature on CD300a expression, regulation, signaling pathways, and ligand interaction, as well as its role in fine tuning immune cell functions and its clinical relevance.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd Metabolism Immunoreceptor Tyrosine-based Inhibition Motif Genetics Phosphatidylethanolamines Antagonists & Inhibitors Phosphatidylserines Receptors, Immunologic Animals Biosynthesis Autoimmune Diseases Ligands Mice Neoplasms Protein Binding Signal Transduction Virus Diseases Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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