NDLI: The lung is protected from spontaneous inflammation by autophagy in myeloid cells.

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The lung is protected from spontaneous inflammation by autophagy in myeloid cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kanayama, Masashi Shinohara, Mari L. He, You-Wen
Description	Author Affiliation: Kanayama M ( Department of Immunology, Duke University Medical Center, Durham, NC 27710); He YW ( Department of Immunology, Duke University Medical Center, Durham, NC 27710); Shinohara ML ( Department of Immunology, Duke University Medical Center, Durham, NC 27710)
Abstract	The lung is constantly exposed to the outer environment; thus, it must maintain a state of immune ignorance or tolerance not to overrespond to harmless environmental stimuli. How cells in the lung control immune responses under nonpathogenic condition is not fully understood. In this study, we found that autophagy plays a critical role in the lung-specific immune regulation that prevents spontaneous inflammation. Autophagy in pulmonary myeloid cells plays a role in maintaining low burdens of environmental microbes in the lung, as well as in lowering mitochondrial reactive oxygen species production and preventing overresponse to TLR4 ligands in alveolar macrophages. Based on these mechanisms, we also found that intranasal instillation of antibiotics or an inhibitor of reactive oxygen species was efficient in preventing spontaneous pulmonary inflammation. Thus, autophagy in myeloid cells, particularly alveolar macrophages, is critical for inhibiting spontaneous pulmonary inflammation, and pulmonary inflammation caused by dysfunctional autophagy is pharmacologically prevented.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1403249
Journal	The Journal of Immunology
Issue Number	11
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autophagy Genetics Lung Immunology Microtubule-associated Proteins Myeloid Cells Pneumonia Animals Anti-bacterial Agents Administration & Dosage Cells, Cultured Environmental Exposure Adverse Effects Immunity, Innate Microbiology Pathology Macrophages, Alveolar Mice Mice, Inbred C57bl Mice, Knockout Mitochondria Reactive Oxygen Species Antagonists & Inhibitors Metabolism Toll-like Receptor 4 Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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