NDLI: Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-ß Therapy.

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Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-ß Therapy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Safavi, Farinaz Ciric, Bogoljub Zhang, Guang-Xian Hwang, Daniel Rasouli, Javad Rostami, Abdolmohamad Leist, Thomas P. Imitola, Jaime Gonnella, Patricia Mahajan, Kedar Mari, Elisabeth R.
Description	Author Affiliation: Rasouli J ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Ciric B ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Imitola J ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Gonnella P ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Hwang D ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Mahajan K ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Mari ER ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Safavi F ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Leist TP ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Zhang GX ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107.); Rostami A ( Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107 Rostami@jefferson.edu.)
Abstract	Multiple sclerosis (MS) is an autoimmune disease of the CNS. Studies in animal models of MS have shown that GM-CSF produced by T cells is necessary for the development of autoimmune CNS inflammation. This suggests that GM-CSF may have a pathogenic role in MS as well, and a clinical trial testing its blockade is ongoing. However, there have been few reports on GM-CSF production by T cells in MS. The objective of this study was to characterize GM-CSF production by T cells of MS patients and to determine the effect of IFN-ß therapy on its production. GM-CSF production by peripheral blood (PB) T cells and the effects of IFN-ß were characterized in samples of untreated and IFN-ß-treated MS patients versus healthy subjects. GM-CSF production by T cells in MS brain lesions was analyzed by immunofluorescence. Untreated MS patients had significantly greater numbers of GM-CSF(+)CD4(+) and CD8(+) T cells in PB compared with healthy controls and IFN-ß-treated MS patients. IFN-ß significantly suppressed GM-CSF production by T cells in vitro. A number of CD4(+) and CD8(+) T cells in MS brain lesions expressed GM-CSF. Elevated GM-CSF production by PB T cells in MS is indicative of aberrant hyperactivation of the immune system. Given its essential role in animal models, abundant GM-CSF production at the sites of CNS inflammation suggests that GM-CSF contributes to MS pathogenesis. Our findings also reveal a potential mechanism of IFN-ß therapy, namely suppression of GM-CSF production.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1403243
Journal	The Journal of Immunology
Issue Number	11
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Cd8-positive T-lymphocytes Granulocyte-macrophage Colony-stimulating Factor Biosynthesis Interferon-beta Therapeutic Use Multiple Sclerosis Drug Therapy Brain Cytology Pathology Inflammation Interferon-gamma Lymphocyte Activation Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-ß Therapy.

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