NDLI: Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children.

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Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children.

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Control of Viremia Enables Acquisition of Resting Memory B Cells with Age and Normalization of Activated B Cell Phenotypes in HIV-Infected Children.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fegan, Greg W. Urban, Britta C. Nduati, Eunice W. Muema, Daniel M. Mwaringa, Shalton M. Hassan, Amin S. Macharia, Gladys N. Berkley, James A.
Description	Author Affiliation: Muema DM ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya); Macharia GN ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya); Hassan AS ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya); Mwaringa SM ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya); Fegan GW ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya); Berkley JA ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya); Nduati EW ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya); Urban BC ( Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Research - Coast, 80108 Kilifi, Kenya)
Abstract	HIV affects the function of all lymphocyte populations, including B cells. Phenotypic and functional defects of B cells in HIV-infected adults have been well characterized, but defects in children have not been studied to the same extent. We determined the proportion of B cell subsets and frequencies of Ag-specific memory B cells in peripheral blood from HIV-infected children and healthy controls, using flow cytometry and B cell ELISPOT, respectively. In addition, we measured the quantities and avidities of plasma Abs against various Ags by ELISA. We also determined plasma levels of BAFF and expression of BAFF receptors on B cells. Children with high HIV viremia had increased proportions of activated mature B cells, tissue-like memory B cells and plasmablasts, and low proportions of naive B cells when compared with community controls and children with low HIV viremia, similar to adults infected with HIV. HIV-infected groups had lower proportions of resting memory B cells than did community controls. Notably, high HIV viremia prevented the age-dependent accumulation of class-switched resting memory B cells. HIV-infected children, regardless of the level of viremia, showed lower quantities and avidities of IgG and lower frequencies of memory B cells against Expanded Program on Immunization vaccines. The HIV-infected children had an altered BAFF profile that could have affected their B cell compartment. Therefore, B cell defects in HIV-infected children are similar to those seen in HIV-infected adults. However, control of HIV viremia is associated with normalization of activated B cell subsets and allows age-dependent accumulation of resting memory B cells.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1500491
Journal	The Journal of Immunology
Issue Number	3
Volume Number	195
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-cell Activating Factor Blood B-cell Activation Factor Receptor Metabolism B-lymphocyte Subsets Immunology Hiv Infections Viremia Antibody Affinity Biosynthesis Child, Preschool Hiv Antibodies Transmission Virology Hiv-1 Immunoglobulin G Immunologic Memory Infant Infant, Newborn Infectious Disease Transmission, Vertical Lymphocyte Activation Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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