NDLI: Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hermans, Ian F. Painter, Gavin F. Farrand, Kathryn J. Ruedl, Christiane Osmond, Taryn L. Petersen, Troels R.
Description	Author Affiliation: Osmond TL ( Malaghan Institute of Medical Research, Wellington 6242, New Zealand); Farrand KJ ( Malaghan Institute of Medical Research, Wellington 6242, New Zealand); Painter GF ( The Ferrier Research Institute, Victoria University of Wellington, Lower Hutt 5010, New Zealand); Ruedl C ( School of Biological Sciences, Nanyang Technological University, Singapore 637551.); Petersen TR ( Malaghan Institute of Medical Research, Wellington 6242, New Zealand); Hermans IF ( Malaghan Institute of Medical Research, Wellington 6242, New Zealand)
Abstract	The function of dendritic cells (DCs) can be modulated through multiple signals, including recognition of pathogen-associated molecular patterns, as well as signals provided by rapidly activated leukocytes in the local environment, such as innate-like T cells. In this article, we addressed the possibility that the roles of different murine DC subsets in cross-priming CD8(+) T cells can change with the nature and timing of activatory stimuli. We show that CD8 (+) DCs play a critical role in cross-priming CD8(+) T cell responses to circulating proteins that enter the spleen in close temporal association with ligands for TLRs and/or compounds that activate NKT cells. However, if NKT cells are activated first, then CD8 (-) DCs become conditioned to respond more vigorously to TLR ligation, and if triggered directly, these cells can also contribute to priming of CD8(+) T cell responses. In fact, the initial activation of NKT cells can condition multiple DC subsets to respond more effectively to TLR ligation, with plasmacytoid DCs making more IFN- and both CD8 (+) and CD8 (-) DCs manufacturing more IL-12. These results suggest that different DC subsets can contribute to T cell priming if provided appropriately phased activatory stimuli, an observation that could be factored into the design of more effective vaccines.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	3
Volume Number	195
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Cross-priming Dendritic Cells Lymphocyte Activation Natural Killer T-cells Animals Antigen Presentation Antigens, Surface Genetics Interferon-alpha Biosynthesis Interleukin-12 Lectins, C-type Mannose-binding Lectins Mice Mice, Inbred C57bl Mice, Transgenic Spleen Toll-like Receptors Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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