| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Bonilla, Nelly Lombes, Amélie Lucas, Bruno Martin, Bruno Charvet, Céline Durand, Aurélie Auffray, Cédric Rivière, Matthieu |
| Description |
Country affiliation: France Author Affiliation: Lombes A ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France); Durand A ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France); Charvet C ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France); Rivière M ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France); Bonilla N ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France); Auffray C ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France); Lucas B ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France); Martin B ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Paris 75014, France) |
| Abstract |
To better apprehend γ/δ T cell biological functions in the periphery, it appears crucial to identify markers highlighting the existence of distinct phenotypic and functional γ/δ T cell subsets. Interestingly, the expression of CD44 and Ly-6C subdivides murine peripheral γ/δ T cells into several subsets, with Ly-6C(-) CD44(hi) γ/δ T cells corresponding to the IL-17-producing CD27(-) γ/δ T cell subset exhibiting innate-like features. By comparing the other subsets to naive and memory CD8(+) /ß T cells, in this study, we show that Ly-6C(- or +) CD44(lo) and Ly-6C(+)CD44(hi) γ/δ T cells greatly resemble, and behave like, their CD8(+) /ß T cell counterparts. First, like memory CD8(+) /ß T cells, Ly-6C(+)CD44(hi) γ/δ T cells are sparse in the thymus but largely increased in proportion in tissues. Second, similarly to naive CD8 /ß T cells, CD44(lo) γ/δ T cells are poorly cycling in vivo in the steady state, and their proportion declines with age in secondary lymphoid organs. Third, CD44(lo) γ/δ T cells undergo spontaneous proliferation and convert to a memory-like Ly-6C(+)CD44(hi) phenotype in response to lymphopenia. Finally, CD44(lo) γ/δ T cells have an intrinsic high plasticity as, upon appropriate stimulation, they are capable of differentiating nonetheless into Th17-like and Th1-like cells but also into fully functional Foxp3(+) induced regulatory T cell-like γ/δ T cells. Thus, peripheral CD27(+) γ/δ T cells, commonly considered as a functionally related T cell compartment, actually share many common features with adaptive /ß T cells, as both lineages include naive-like and memory-like lymphocytes with distinct phenotypic, functional, and homeostatic characteristics. |
| ISSN |
00221767 |
| e-ISSN |
15506606 |
| Journal |
The Journal of Immunology |
| Issue Number |
4 |
| Volume Number |
195 |
| Language |
English |
| Publisher |
The American Association of Immunologists |
| Publisher Date |
2015-08-15 |
| Publisher Place |
United States |
| Access Restriction |
Open |
| Subject Keyword |
Adaptive Immunity Receptors, Antigen, T-cell, Alpha-beta Metabolism Receptors, Antigen, T-cell, Gamma-delta T-lymphocyte Subsets Immunology Animals Antigens, Cd27 Antigens, Cd44 Genetics Antigens, Ly Gene Expression Homeostasis Immunophenotyping Interleukin-17 Biosynthesis Lymphopenia Mice Mice, Knockout Phenotype Signal Transduction Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Immunology and Allergy Immunology |
