NDLI: Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia.

Please wait, while we are loading the content...

Year: 2016 Volume: 101

Year: 2015 Volume: 100

Year: 2014 Volume: 99

Year: 2013 Volume: 98

Year: 2012 Volume: 97

Year: 2012 Volume: 97 Issue: 12

Year: 2012 Volume: 97 Issue: 11

Year: 2012 Volume: 97 Issue: 10

Hidden culprit of primary hyperparathyroidism.

Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging.

Screening of Cushing's syndrome in outpatients with type 2 diabetes: results of a prospective multicentric study in Italy.

Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease.

Ethinyl estradiol-cyproterone acetate versus low-dose pioglitazone-flutamide-metformin for adolescent girls with androgen excess: divergent effects on CD163, TWEAK receptor, ANGPTL4, and LEPTIN expression in subcutaneous adipose tissue.

A new combination of testosterone and nestorone transdermal gels for male hormonal contraception.

Combined effects of the variants FSHB -211G>T and FSHR 2039A>G on male reproductive parameters.

Quality of life and anxiety in adolescents with differentiated thyroid cancer.

Update in utility of secondary node dissection for papillary thyroid cancer.

Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia.

Pulmonary metastases due to a giant-cell tumor of bone.

Changes of serum soluble receptor activator for nuclear factor-κB ligand after glucocorticoid therapy reflect regulation of its expression by osteoblasts.

Chemerin regulates NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy.

Six months of parathyroid Hormone (1-84) administered concurrently versus sequentially with monthly ibandronate over two years: the PTH and ibandronate combination study (PICS) randomized trial.

Endocrine and clinical correlates of myostatin serum concentration in men--the STRAMBO study.

Dexamethasone induces germ cell apoptosis in the human fetal ovary.

Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A.

Cabergoline-induced pneumocephalus in a medically treated macroprolactinoma.

Differences in risk factors for coronary heart disease among diabetic and nondiabetic individuals from a population with high rates of diabetes: the Strong Heart Study.

A cross-sectional study of the relationship between cortical bone and high-impact activity in young adult males and females.

Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas.

Microarchitectural abnormalities are more severe in postmenopausal women with vertebral compared to nonvertebral fractures.

Pituitary function in patients with normal pressure hydrocephalus before and after neurosurgical correction.

Neonatal body composition according to the revised institute of medicine recommendations for maternal weight gain.

Successful treatment of tumor-induced osteomalacia with CT-guided percutaneous ethanol and cryoablation.

Sunitinib in refractory adrenocortical carcinoma: a phase II, single-arm, open-label trial.

The utility of menstrual cycle length as an indicator of cumulative hormonal exposure.

Polycystic ovary syndrome with hyperandrogenism is characterized by an increased risk of hepatic steatosis compared to nonhyperandrogenic PCOS phenotypes and healthy controls, independent of obesity and insulin resistance.

Effects of exercise on sRAGE levels and cardiometabolic risk factors in patients with type 2 diabetes: a randomized controlled trial.

Circulating sclerostin levels are decreased in patients with endogenous hypercortisolism and increase after treatment.

A novel tool in the diagnosis and follow-up of (cyclic) Cushing's syndrome: measurement of long-term cortisol in scalp hair.

Measurements of serum DHEA and DHEA sulphate levels improve the accuracy of the low-dose cosyntropin test in the diagnosis of central adrenal insufficiency.

Comparative effectiveness of basal-bolus versus premix analog insulin on glycemic variability and patient-centered outcomes during insulin intensification in type 1 and type 2 diabetes: a randomized, controlled, crossover trial.

Vasomotor symptoms and insulin resistance in the study of women's health across the nation.

Increased tenascin C and Toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity.

Agenesis of internal carotid artery and hypopituitarism: case report and review of literature.

Potential role for retinoic acid in patients with Cushing's disease.

Vildagliptin reduces glucagon during hyperglycemia and sustains glucagon counterregulation during hypoglycemia in type 1 diabetes.

The effect of vitamin D on calcium absorption in older women.

Sclerostin levels associated with inhibition of the Wnt/ß-catenin signaling and reduced bone turnover in type 2 diabetes mellitus.

Association between physical activity and urinary estrogens and estrogen metabolites in premenopausal women.

Characterization of the cortisol stress response to sedation and anesthesia in children.

Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study.

Clinical review: Current state and future perspectives in the diagnosis of diabetes insipidus: a clinical review.

Mutation of the CYP2R1 vitamin D 25-hydroxylase in a Saudi Arabian family with severe vitamin D deficiency.

Involvement of hypothalamus autoimmunity in patients with autoimmune hypopituitarism: role of antibodies to hypothalamic cells.

A Mediterranean Diet Enriched with Olive Oil Is Associated with Higher Serum Total Osteocalcin Levels in Elderly Men at High Cardiovascular Risk

Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas.

Total thyroidectomy in patients with amiodarone-induced thyrotoxicosis and severe left ventricular systolic dysfunction.

Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus.

Physical activity in relation to serum sclerostin, insulin-like growth factor-1, and bone turnover markers in healthy premenopausal women: a cross-sectional and a longitudinal study.

Pubertal timing, androgens, and obesity phenotypes in women at midlife.

Moderate ovarian stimulation does not increase the incidence of human embryo chromosomal abnormalities in in vitro fertilization cycles.

Longitudinal assessment of bone density and structure in childhood survivors of acute lymphoblastic leukemia without cranial radiation.

Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT.

Fracture risk assessment without race/ethnicity information.

GADA titer-related risk for organ-specific autoimmunity in LADA subjects subdivided according to gender (NIRAD study 6).

Clinical review: The thyroid in mind: cognitive function and low thyrotropin in older people.

Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) are allelic variants caused by GLUT2 mutations.

Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon.

Down-Regulation of S100A11, a Calcium-Binding Protein, in Human Endometrium May Cause Reproductive Failure

Impact of antenatal synthetic glucocorticoid exposure on endocrine stress reactivity in term-born children.

CRH Activation of Different Signaling Pathways Results in Differential Calcium Signaling in Human Pregnant Myometrium before and during Labor

Glucocorticoid replacement and mortality in patients with nonfunctioning pituitary adenoma.

Role of 11ßHSD type 2 enzyme activity in essential hypertension and children with chronic kidney disease (CKD).

Oxytocin secretion is associated with severity of disordered eating psychopathology and insular cortex hypoactivation in anorexia nervosa.

Effect of tight glucose control with insulin on the thyroid axis of critically ill children and its relation with outcome.

Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans.

Increased cellular and circulating biomarkers of oxidative stress in nascent metabolic syndrome.

Functional magnetic resonance imaging analysis of food-related brain activity in patients with lipodystrophy undergoing leptin replacement therapy.

Plasma Sphingosine 1-Phosphate Levels and the Risk of Vertebral Fracture in Postmenopausal Women

Fetal insulin and IGF-II contribute to gestational diabetes mellitus (GDM)-associated up-regulation of membrane-type matrix metalloproteinase 1 (MT1-MMP) in the human feto-placental endothelium.

Role of calcium deficiency in development of nutritional rickets in Indian children: a case control study.

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

A clinical prediction score to diagnose unilateral primary aldosteronism.

Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed.

Approach to the patient with extremely low HDL-cholesterol.

Primary aldosteronism: clinical lateralization and costs.

Quality of life in adolescent patients with differentiated thyroid cancer: moving beyond survival.

Antenatal glucocorticoid treatment: are we doing harm to term babies?

Year: 2012 Volume: 97 Issue: 9

Year: 2012 Volume: 97 Issue: 8

Year: 2012 Volume: 97 Issue: 7

Year: 2012 Volume: 97 Issue: 6

Year: 2012 Volume: 97 Issue: 5

Year: 2012 Volume: 97 Issue: 4

Year: 2012 Volume: 97 Issue: 3

Year: 2012 Volume: 97 Issue: 2

Year: 2012 Volume: 97 Issue: 1

Year: 2011 Volume: 96

Year: 2010 Volume: 95

Year: 2009 Volume: 94

Year: 2008 Volume: 93

Year: 2007 Volume: 92

Year: 2006 Volume: 91

Year: 2005 Volume: 90

Year: 2004 Volume: 89

Year: 2003 Volume: 88

Year: 2002 Volume: 87

Year: 2001 Volume: 86

Year: 2000 Volume: 85

Year: 1999 Volume: 84

Year: 1998 Volume: 83

Year: 1972 Volume: 35

Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chigusa, Yoshitsugu Mogami, Haruta Fujita, Kohei Tatsumi, Keiji Nishimura, Fumitomo Kondoh, Eiji Konishi, Ikuo
Description	Country affiliation: Japan Author Affiliation: Chigusa Y ( Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan.)
Abstract	CONTEXT: Serum concentration of oxidized low-density lipoprotein (oxLDL) is higher in women with preeclampsia than in normal pregnant woman. Lectin-like oxLDL receptor-1 (LOX-1) is one of the scavenger receptors for oxLDL and is abundantly expressed in placenta. It is well known that oxLDL activates nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and cytoprotective genes such as heme oxygenase-1 (HO-1), which play an important role in preeclampsia. However, it has yet to be elucidated whether LOX-1, along with Nrf2, participates in the pathology of preeclampsia. OBJECTIVE: The objective of the study was to assess LOX-1 expression and Nrf2 activation in preeclamptic placentas and to manifest their physiological roles in preeclampsia. METHODS: Expression and regulation of LOX-1, HO-1, and Nrf2 were evaluated by real-time quantitative RT-PCR and Western blotting. The functions of LOX-1 and Nrf2 were examined using an anti-LOX-1 antibody and Nrf2 activator in JAR, a choriocarcinoma cell line, and placental explants. RESULTS: Both LOX-1 expression and Nrf2 activation were significantly decreased in preeclamptic placentas compared with normal controls. A significant decrease in LOX-1 mRNA was found in placental explant cultures under hypoxic conditions. Activation of Nrf2 up-regulated HO-1 in both the JAR cells and placental explants. Furthermore, oxLDL increased HO-1 mRNA, whereas the blockade of LOX-1 inhibited the increase of HO-1 mRNA in JAR cells. CONCLUSION: Decreasing LOX-1 expression in preeclamptic placenta may contribute to high oxLDL concentration, low Nrf2 activation, and low HO-1 expression. These findings provide novel insights into the crucial role of LOX-1 and Nrf2 in the pathogenesis of preeclampsia.
ISSN	0021972X
e-ISSN	19457197
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	10
Volume Number	97
Language	English
Publisher	Oxford University Press
Publisher Date	2012-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Lipoproteins, Ldl Metabolism Nf-e2-related Factor 2 Placenta Pre-eclampsia Scavenger Receptors, Class E Antioxidants Cell Line, Tumor Choriocarcinoma Chorionic Villi Pathology Heme Oxygenase-1 Genetics Anoxia Pregnancy Rna, Messenger Uterine Neoplasms Research Support, Non-u.s. Gov't Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in