NDLI: Low circulating adropin concentrations with obesity and aging correlate with risk factors for metabolic disease and increase after gastric bypass surgery in humans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	St-Onge, Marie-Pierre Stanhope, Kimber L. Ali, Mohamed R. Ravussin, Eric Havel, Peter J. Tam, Charmaine S. Butler, Andrew A. Wolfe, Bruce M. O'Keeffe, Majella
Description	Country affiliation: United States Author Affiliation: Butler AA ( Department of Metabolism and Aging, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, USA. abutler@scripps.edu)
Abstract	CONTEXT: Mouse studies suggest that adropin, a peptide hormone, is required for metabolic homeostasis and prevention of obesity-associated insulin resistance. Whether obesity and insulin resistance are associated with low plasma adropin levels in humans is not known. OBJECTIVES: Our objective was to investigate the hypothesis that obesity and indicators of insulin resistance are associated with low adropin levels and determine whether weight loss regulates adropin levels. DESIGN AND PARTICIPANTS: Plasma was obtained from 85 female [age 21-67 yr, body mass index (BMI) 19.4-71.5 kg/m2] and 45 male (age 18-70 yr, BMI 19.1-62.6 kg/m2) volunteers for other clinical studies. The impact of Roux-en-Y gastric bypass was investigated in 19 obese females (BMI 37-65 kg/m2) using samples collected at baseline and 1-12 months after surgery. RESULTS: Adropin levels correlate negatively with BMI (r=-0.335, P<0.001) and age (r=-0.263, P=0.003). Age-adjusted adropin levels are higher in males [4.1 ng/ml; 95% confidence interval (CI)=3.6-4.6 ng/ml] than females (3.0 ng/ml; 95% CI=2.6-3.4 ng/ml) (P=0.001). In all subjects, lower age-adjusted adropin levels were observed in overweight (3.3 ng/ml; 95% CI=2.8-3.8 ng/ml, P=0.033) and obese (2.7 ng/ml; 95% CI=2.1-3.3 ng/ml, P=0.001) compared with healthy-weight subjects (4.1 ng/ml; 95% CI=3.6-4.5 ng/ml). This effect was gender specific (weight category×gender, P<0.001) and was observed in males only. Aging and diagnosis with two or more metabolic syndrome risk factors was associated with low adropin levels, irrespective of sex. Adropin concentrations increased after Roux-en-Y gastric bypass, peaking 3 months after surgery (P<0.01). CONCLUSIONS: Although males exhibit higher adropin levels that are reduced by obesity, aging and markers of insulin resistance are associated with low plasma adropin irrespective of sex.
ISSN	0021972X
e-ISSN	19457197
DOI	10.1210/jc.2012-2194
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	10
Volume Number	97
Language	English
Publisher	Oxford University Press
Publisher Date	2012-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blood Proteins Metabolism Gastric Bypass Insulin Resistance Physiology Metabolic Diseases Epidemiology Obesity Adolescent Aging Dyslipidemias Homeostasis Surgery Peptides Postoperative Period Risk Factors Sex Distribution Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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