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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mattaliano, Mark D. Wooters, Joe Shih, Heather H. Paulsen, Janet E. |
| Description | Country affiliation: United States Author Affiliation: Mattaliano MD ( Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA.) |
| Abstract | Oxidatively modified low-density lipoprotein (OxLDL) is a contributing factor of endothelial dysfunction, an early cellular event during atherogenesis. In endothelial cells, OxLDL has been shown to stimulate proinflammatory responses, increase lipid accumulation, and induce the expression of adhesion and extracellular matrix degrading molecules. The primary receptor for OxLDL on endothelial cells has been identified as a member of the scavenger receptor family called lectin-like OxLDL receptor-1 (LOX-1). A number of studies on LOX-1 have implicated its role in multiple cardiovascular diseases including atherosclerosis. To better understand the molecular mechanisms underlying the role of LOX-1 in endothelial cells, we identified interacting proteins in an affinity-purified LOX-1 receptor complex from human aortic endothelial HAECT cells by mass spectrometry. Two molecules involved in Rho signaling pathway, ARHGEF1 and ROCK2, were identified, and their associations with LOX-1 were confirmed in reciprocal immunoprecipitation studies. Particularly, ROCK2 was found to dynamically associate with LOX-1 in the presence of OxLDL. In addition, OxLDL treatment stimulated ROCK2 catalytic activity, and ROCK2 inhibition attenuated NF-kappaB activation and IL-8 production resulting from OxLDL activation of LOX-1. In summary, a functional proteomics approach has enabled us to identify novel LOX-1 interactors that potentially contribute to the cellular and signaling functions of LOX-1. |
| File Format | HTM / HTML |
| ISSN | 03636143 |
| e-ISSN | 15221563 |
| Journal | American Journal of Physiology - Cell Physiology |
| Issue Number | 5 |
| Volume Number | 298 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2010-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology Endothelial Cells Metabolism Interleukin-8 Lipoproteins, Ldl Scavenger Receptors, Class E Rho-associated Kinases Cell Line Chemokine Cxcl2 Genetics Pharmacology Nf-kappa B |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology |
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