NDLI: Preablation 131-I scans with SPECT/CT contribute to thyroid cancer risk stratification and 131-I therapy planning.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Esfandiari, Nazanene H. Wong, Ka Kit Avram, Anca M.
Description	Author Affiliation: Avram AM ( Nuclear Medicine, Department of Radiology (A.M.A., K.K.W.), and Endocrinology, Department of Internal Medicine (N.H.E.), University of Michigan, Ann Arbor, Michigan)
Abstract	CONTEXT: The use of preablation diagnostic radioiodine scans for risk stratification and radioiodine therapy planning for differentiated thyroid cancer (DTC) remains controversial. OBJECTIVE: The objective was to assess the contribution of preablation diagnostic 131-I scans with SPECT/CT (Dx 131-I scan) to (1) the risk stratification and (2) the postoperative management of DTC. DESIGN: The study was designed as a prospective sequential patient series. SETTING: The study was conducted at a University hospital. PATIENTS: Three hundred twenty patients (pts) with DTC (219F; 101M, mean age 47.3 ± 16.4 y, range 10-90) were studied. INTERVENTION: Using clinical and histopathology information an endocrinologist performed risk stratification and determined postoperative management with respect to radioiodine therapy (RAI) planning. The decision to withhold or to administer RAI, and the recommended low, medium or high therapeutic 131-I activity were recorded. Dx 131-I scans were performed and interpreted by two nuclear medicine physicians as showing thyroid remnant, cervical nodal, or distant metastases. The endocrinologist then reperformed risk stratification and reformulated management after consideration of Dx 131-I scans and stimulated thyroglobulin (Tg) information. MAIN OUTCOME MEASURE: Main outcome measures were changes in risk stratification and management after Dx 131-I scans. RESULTS: Detection of unsuspected nodal and distant metastases and elevated stimulated Tg levels resulted in a change in the estimated risk of recurrence in 15% of patients, and management in 31% of patients, as compared to initial risk stratification and management based on histopathology alone. CONCLUSIONS: Both imaging data and stimulated thyroglobulin levels acquired at the time of Dx 131-I scans are consequential for 131-I therapy planning, providing information that changes risk stratification in 15% of patients as compared to recurrence risk estimation based on histopathology alone. Dx 131-I scans contribute to risk stratification by defining residual nodal and distant metastatic disease, changing clinical management in 29.4% of patients.
ISSN	0021972X
e-ISSN	19457197
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	5
Volume Number	100
Language	English
Publisher	Oxford University Press
Publisher Date	2015-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Iodine Radioisotopes Therapeutic Use Thyroid Gland Thyroid Neoplasms Adolescent Administration & Dosage Prospective Studies Radiotherapy Dosage Risk Assessment Radiotherapy Tomography, Emission-computed, Single-photon Whole Body Imaging Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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