NDLI: Serum thyroid hormone autoantibodies in type 1 diabetes mellitus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Di Benedetto, Antonino Pintaudi, Basilio Di Vieste, Giacoma Vita, Roberto Benvenga, Salvatore
Description	Country affiliation: Italy Author Affiliation: Benvenga S ( Department of Clinical and Experimental Medicine (R.V.), Master Program on Childhood, Adolescent and Women's Endocrine Health (S.B.), University of Messina School of Medicine, 98125 Messina, Italy)
Abstract	CONTEXT: Autoimmune thyroid diseases (AITDs) can be associated with type 1 diabetes (DM1). The prevalence of serum antibodies against thyroid hormones (THAb) in subjects with autoimmune diseases other than DM1 is increasing. No data are available for DM1. OBJECTIVE: The objectives were evaluate the rate of associated AITD; the rate of positiveness for serum THAb; the panel of THAb based on thyroid hormone interaction and on Ig class; and the association of AITD alone, THAb alone, or AITD plus THAb with diabetes-related complications. DESIGN: This was an observational, prospective study with 6-year (2005-2011) follow-up. SETTING: The setting was an outpatient diabetes clinic. PATIENTS: Fifty-two consecutive subjects (53.8% males; mean age, 37.4 ± 7.4 y; diabetes duration, 19.9 ± 8.2 y) with DM1. All participants completed the study. MAIN OUTCOME MEASURES: Main outcome measures were AITD rate; THAb positivity according to hormone interaction and Ig class; association of AITD and THAb with diabetes-related complications. RESULTS: AITD rate increased from baseline (34.6%) to follow-up (38.5%). Subjects with DM1 had a high prevalence of THAb (92.3%). The presence of AITD at baseline was associated with subsequent development of macroangiopathy (0 vs 33% at baseline and follow-up, respectively; P = .029). Some THAb patterns, the majority having T3 binding in common, were associated with the progression and development of diabetes-related complications. CONCLUSIONS: THAb synthesis in DM1 might be driven by increased glycosylation of thyroglobulin. Anti T3-THAb may cause a relative 'tissue hypothyroidism' by sequestering thyroid hormone, this at least partially contributing to worsening diabetes-related vascular complications. In a clinical setting THAb positivity could identify subjects more likely to develop diabetes complications.
ISSN	0021972X
e-ISSN	19457197
Journal	The Journal of Clinical Endocrinology & Metabolism
Issue Number	5
Volume Number	100
Language	English
Publisher	Oxford University Press
Publisher Date	2015-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoantibodies Blood Autoantigens Immunology Diabetes Mellitus, Type 1 Iodide Peroxidase Iron-binding Proteins Thyroglobulin Prospective Studies Discipline Endocrinology Discipline Metabolism
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical) Endocrinology, Diabetes and Metabolism Clinical Biochemistry Biochemistry Endocrinology

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