NDLI: Smoking, heart rate, and ischemic stroke: a population-based prospective cohort study among Inner Mongolians in China.

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Smoking, heart rate, and ischemic stroke: a population-based prospective cohort study among Inner Mongolians in China.

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Smoking, heart rate, and ischemic stroke: a population-based prospective cohort study among Inner Mongolians in China.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Aili Xu, Tian Li, Hongmei Xu, Tan Zhang, Yonghong Sun, Yingxian Bu, Xiaoqing Tong, Weijun Zhang, Mingzhi
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Xu T ( Department of Epidemiology, Medical College of Soochow University, Suzhou, China.)
Abstract	BACKGROUND AND PURPOSE: Smoking is a major public health challenge and an important risk factor for cardiovascular diseases. No previous studies have evaluated the association among smoking, heart rate, and ischemic stroke in an Inner Mongolian population. We aim to evaluate the cumulative effect of smoking and heart rate on ischemic stroke incidence in this population. METHODS: A prospective cohort study from June 2003 through July 2012 was conducted among 2530 people ≥20 years of age from Inner Mongolia, China. We categorized the participants into 4 subgroups according to smoking status and heart rate. Cox proportional hazards models and receiver operating characteristic curves were used to evaluate the association among smoking, heart rate, and ischemic stroke. RESULTS: The multivariate-adjusted hazard ratios (95% confidence intervals) of ischemic stroke incidence for nonsmokers with heart rate ≥80 bpm, smokers with heart rate <80 bpm, and smokers with heart rate ≥80 bpm were 1.42 (0.62-3.28), 2.11 (1.06-4.23), and 2.86 (1.33-6.14), respectively, compared with nonsmokers with heart rate <80 bpm. The area under receiver operating characteristic curve (area under the curve) for a model containing smoking status and heart rate, along with conventional factors (area under the curve=0.755), was significantly (P=0.018) larger than the one containing only conventional factors (area under the curve=0.739). CONCLUSIONS: Our study indicated that smoking was an independent risk factor of ischemic stroke, and smokers with faster heart rate had the highest risk of ischemic stroke among Inner Mongolians. These findings suggest that smoking status and heart rate may be valuable in predicting ischemic stroke incidence.
ISSN	00392499
e-ISSN	15244628
Journal	Stroke
Issue Number	9
Volume Number	44
Language	English
Publisher	Lippincott Williams & Wilkins (on behalf of the American Heart Association)
Publisher Date	2013-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Ischemia Epidemiology Heart Rate Physiology Smoking Stroke Ethnology Etiology Predictive Value Of Tests Prospective Studies Comparative Study Research Support, Non-u.s. Gov't Discipline Cardiology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical)

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