NDLI: Single subcortical infarction and atherosclerotic plaques in the middle cerebral artery: high-resolution magnetic resonance imaging findings.

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Single subcortical infarction and atherosclerotic plaques in the middle cerebral artery: high-resolution magnetic resonance imaging findings.

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Single subcortical infarction and atherosclerotic plaques in the middle cerebral artery: high-resolution magnetic resonance imaging findings.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yoon, Youngshin Kim, Jong S. Lee, Deok Hee Kang, Dong-Wha Kwon, Sun U.
Description	Author Affiliation: Yoon Y ( Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea.)
Abstract	BACKGROUND AND PURPOSE: Single subcortical infarction (SSI) may be classified as proximal SSI (pSSI) or distal SSI (dSSI) according to its extension to the middle cerebral artery (MCA). We investigated the differences between pSSI and dSSI in terms of their clinical features, lesion size, and the frequency of MCA plaques detected by high-resolution MRI. METHODS: Thirty-nine patients with SSI (20 pSSI and 19 dSSI) were prospectively enrolled who did not show relevant MCA disease on MR angiography. Lesion size, neurological status (initial National Institutes of Health Stroke Scale score and modified Rankin Scale at 3 months), and the presence and location (superior versus inferior) of high-resolution MRI-identified plaques were evaluated. RESULTS: The frequencies of MCA plaques did not differ between patients with pSSI and those with dSSI (8 [40%] versus 12 [63.2%]; P=0.205); however, superiorly located plaques were significantly more common in patients with pSSI than in those with dSSI (6 [75%] versus 2 [16.7%]; P=0.019). Initial lesion volumes were larger (1.96±1.18 versus 1.11±1.11 mm(3); P=0.025), National Institutes of Health Stroke Scale scores were higher (5 [3-6.75] versus 3 [1-3] points; P=0.017), and microbleeds were fewer (1 [5%] versus 10 [52.6%]; P=0.001) in patients with pSSI than in those with dSSI. Three-month modified Rankin Scale scores were higher in patients with superior plaques than in those with inferior plaques. CONCLUSIONS: Compared with dSSI, pSSI is closely associated with large lesions, severe clinical symptoms, and superiorly located MCA plaques, suggesting that the location, rather than simple presence of plaques, determines the SSI location.
ISSN	00392499
e-ISSN	15244628
Journal	Stroke
Issue Number	9
Volume Number	44
Language	English
Publisher	Lippincott Williams & Wilkins (on behalf of the American Heart Association)
Publisher Date	2013-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebral Infarction Pathology Magnetic Resonance Imaging Middle Cerebral Artery Plaque, Atherosclerotic Classification Magnetic Resonance Angiography Instrumentation Diagnosis Predictive Value Of Tests Prospective Studies Sensitivity And Specificity Severity Of Illness Index Comparative Study Research Support, Non-u.s. Gov't Discipline Cardiology
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine Neuroscience Advanced and Specialized Nursing Neurology (clinical)

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