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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huang, Lizhen Guo, Jingjing Ge, Xia He, Jiang Lu, Ruihua |
| Description | Author Affiliation: Huang L ( State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.) |
| Abstract | The supramolecular interaction of MAH-ß-cyclodextrin (MAH-ß-CD, a modified ß-cyclodextrin carrying seven vinyl carboxylic acid groups) and meferamic acid (MF) has been studied by spectrofluorimetry. The results showed that MAH-ß-CD reacted with MF to form a host-guest complex (MAH-ß-CD-MF) with stoichiometry (1:1) and the inclusion constant (K=7.15×10(2) L/mol) was ascertained by the typical double reciprocal plots. From the phase-solubility diagram, an increase in the water solubility of the drug was observed and the apparent stability constant (K(1:1)) was calculated to be 8.62×10(2) L/mol. Furthermore, the thermodynamic parameters (ΔG°, ΔH° and ΔS°) of MAH-ß-CD-MF were obtained and the inclusion mechanism was also preliminarily discussed. In order to further confirm the experimental results, investigation on the molecular modeling was performed. On the basis of the significant enhancement of the fluorescence intensity of MF, a spectrofluorimetric method for MF determination in bulk aqueous solution in the presence of MAH-ß-CD was developed. The linear range was 2.00×10(-8)-9.00×10(-5) mol/L and the detection limit was 3.36×10(-9) mol/L. The proposed method was successfully applied to determine MF in tablets, serum and urine with the satisfactory result. |
| ISSN | 13861425 |
| Issue Number | 5 |
| Volume Number | 78 |
| e-ISSN | 18733557 |
| Journal | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Spectrometry, Fluorescence Methods Beta-cyclodextrins Analysis Chemistry Acids Blood Urine Buffers Humans Hydrogen-ion Concentration Kinetics Models, Molecular Solubility Solutions Tablets Thermodynamics Time Factors Journal Article Research Support, Non-u.s. Gov't Discipline Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Atomic and Molecular Physics, and Optics Analytical Chemistry Instrumentation |
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