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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Miller, Thomas H. McEneff, Gillian L. Owen, Stewart F. Barron, Leon P. Brown, Rebecca J. Bury, Nicolas R. |
| Description | Country affiliation: United kingdom Author Affiliation: Miller TH ( Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College London, 150 Stamford Street, London SE1 9NH, UK.); McEneff GL ( Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College London, 150 Stamford Street, London SE1 9NH, UK.); Brown RJ ( AstraZeneca, Global Environment, Alderley Park, Macclesfield, Cheshire SK10 4TF, UK.); Owen SF ( AstraZeneca, Global Environment, Alderley Park, Macclesfield, Cheshire SK10 4TF, UK.); Bury NR ( Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College London, 150 Stamford Street, London SE1 9NH, UK.); Barron LP ( Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College London, 150 Stamford Street, London SE1 9NH, UK. Electronic address: leon.barron@kcl.ac.uk.) |
| Abstract | The development, characterisation and application of a new analytical method for multi-residue PPCP determination in the freshwater amphipod, Gammarus pulex are presented. Analysis was performed using pulverised liquid extraction (PuLE), solid phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Qualitative method performance offered excellent limits of detection at <20 ng g(-1) for 18 out of 29 compounds. For quantitative application, linearity and precision were considered acceptable for 10 compounds across the ng-µg g(-1) range (R2≥0.99; ≤20% relative standard deviation respectively). The method was applied to the analysis of G. pulex and river water sourced from six tributaries of the River Thames. Carbamazepine, diazepam, nimesulide, trimethoprim and warfarin were determined in G. pulex samples at low ng g(-1) (dry weight) concentrations across these sites. Temazepam and diclofenac were also detected, but were not quantifiable. Six pharmaceuticals were quantified in surface waters across the eight sites at concentrations ranging from 3 to 344 ng L(-1). The possibility for confirmatory detection and subsequent quantification of pharmaceutical residues in benthic organisms such as G. pulex will enable further understanding on the susceptibility and ecological effects of PPCPs in the aquatic environment. |
| ISSN | 00489697 |
| Volume Number | 511 |
| e-ISSN | 18791026 |
| Journal | Science of The Total Environment |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Amphipoda Chemistry Environmental Monitoring Methods Pharmaceutical Preparations Analysis Water Pollutants, Chemical Animals Chromatography, Liquid Fresh Water Solid Phase Extraction Tandem Mass Spectrometry Journal Article Research Support, Non-u.s. Gov't Discipline Environmental Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Environmental Chemistry Waste Management and Disposal Pollution Environmental Engineering |
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