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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Evans, Sian E. Davies, Paul Lubben, Anneke Kasprzyk-Hordern, Barbara |
| Description | Country affiliation: United kingdom Author Affiliation: Evans SE ( University of Bath, Department of Chemistry, Faculty of Science, Bath BA2 7AY, UK.); Davies P ( University of Bath, Department of Chemistry, Faculty of Science, Bath BA2 7AY, UK.); Lubben A ( University of Bath, Department of Chemistry, Faculty of Science, Bath BA2 7AY, UK.); Kasprzyk-Hordern B ( University of Bath, Department of Chemistry, Faculty of Science, Bath BA2 7AY, UK. Electronic address: b.kasprzyk-hordern@bath.ac.uk.) |
| Abstract | This is the first study presenting a multi-residue method allowing for comprehensive analysis of several chiral pharmacologically active compounds (cPACs) including beta-blockers, antidepressants and amphetamines in wastewater and digested sludge at the enantiomeric level. Analysis of both the liquid and solid matrices within wastewater treatment is crucial to being able to carry out mass balance within these systems. The method developed comprises filtration, microwave assisted extraction and solid phase extraction followed by chiral liquid chromatography coupled with tandem mass spectrometry to analyse the enantiomers of 18 compounds within all three matrices. The method was successfully validated for 10 compounds within all three matrices (amphetamine, methamphetamine, MDMA, MDA, venlafaxine, desmethylvenlafaxine, citalopram, metoprolol, propranolol and sotalol), 7 compounds validated for the liquid matrices only (mirtazapine, salbutamol, fluoxetine, desmethylcitalopram, atenolol, ephedrine and pseudoephedrine) and 1 compound (alprenolol) passing the criteria for solid samples only. The method was then applied to wastewater samples; cPACs were found at concentration ranges in liquid matrices of: 1.7 ng L(-1) (metoprolol) - 1321 ng L(-1) (tramadol) in influent, |
| File Format | HTM / HTML |
| ISSN | 00032670 |
| Volume Number | 882 |
| e-ISSN | 18734324 |
| Journal | Analytica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-02 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Chromatography, Liquid Methods Pharmaceutical Preparations Analysis Sewage Chemistry Solid Phase Extraction Street Drugs Tandem Mass Spectrometry Water Pollutants, Chemical Microwaves Stereoisomerism Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry |
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