NDLI: Excess of activating killer cell immunoglobulinlike receptors and lack of HLA-Bw4 ligands: a twoedged weapon in chronic fatigue syndrome.

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Excess of activating killer cell immunoglobulinlike receptors and lack of HLA-Bw4 ligands: a twoedged weapon in chronic fatigue syndrome.

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Excess of activating killer cell immunoglobulinlike receptors and lack of HLA-Bw4 ligands: a twoedged weapon in chronic fatigue syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Carlo-Stella, Nicoletta Salvaneschi, Laura Bozzini, Sara Martinetti, Miryam Pasi, Annamaria Cuccia, Mariaclara Bombardieri, Stefano De Silvestri, Annalisa
Spatial Coverage	Italy
Description	Country affiliation: Italy Author Affiliation: Pasi A ( HLA Laboratory, Immunohaematology and Transfusion Center, Pavia, Italy.)
Abstract	Chronic fatigue syndrome (CFS) is an inflammatory disease of unknown aetiology. Researchers have proposed infectious, neurological and immunological causes of this syndrome. Recently, the xenotropic murine leukemia virus-related virus was detected in 67% of patients with CFS in a US study. This observation is in agreement with one ascertained aspect of the disease: a decreased efficiency in NK cell lytic activity in CFS patients. Here, we analyzed the genomic polymorphism of killer cell immunoglobulin-like receptors (KIRs) and their HLA class I cognate ligands in patients with certified CFS. An excess of KIR3DS1 was found in CFS patients with respect to controls, as well as an increased frequency of the genotype missing KIR2DS5. Forty-four CFS patients and 50 controls also underwent genomic typing for the HLA-ligands. In the patients, a great proportion of KIR3DL1 and KIR3DS1 receptors were found to be missing their HLA-Bw4Ile80 binding motif. We hypothesize that an excess of KIR3DS1, combined with an excess of ligand-free KIR3DL1 and KIR3DS1 receptors, may hamper the clearance of a pathogen via NK cells, thus favouring the chronicity of the infection.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	4
Language	English
Publisher	Spandidos Publications
Publisher Date	2011-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Fatigue Syndrome, Chronic Immunology Hla-b Antigens Receptors, Kir Case-control Studies Genetics Heterozygote Ligands Linkage Disequilibrium Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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Excess of activating killer cell immunoglobulinlike receptors and lack of HLA-Bw4 ligands: a twoedged weapon in chronic fatigue syndrome.