NDLI: Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming growth factor ß1.

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Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming growth factor ß1.

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Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming growth factor ß1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liu, Fenye Zhang, Jidong Liu, Guilin Wang, Bo Ren, Min Jiang, Hong Lv, Yijing Liu, Ping
Description	Author Affiliation: Ren M ( Department of Traditional Chinese Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, PR China.)
Abstract	Transforming growth factor ß1 (TGF-ß1) is a known pleiotropic growth factor in cell proliferation, migration and phenotypic transition. Fibroblasts are considered the most reactive in the vascular wall. We aimed to explore the effect and mechanism of TGF-ß1 on aortal adventitial fibroblasts (AFs) induced by TGF-ß1. AFs were cultured in vitro by tissue explants. After stimulation by TGF-ß1 and treatment with small interfering RNA (siRNA)-Smad2 and siRNA-Smad3, MTT and the transwell chamber techniques were used for assessing AF proliferation and migration. The expression of phospho (pho)-Smad2, pho-Smad3, Smad7, -smooth muscle actin (SMA) and collagen I and III were evaluated by Western blot analysis and real-time RT-PCR. After stimulation by TGF-ß1 for 24 h, the proliferation and migration of treated AFs were higher compared to those of untreated AFs, as was the expression of Smad2, Smad3, pho-Smad2, pho-Smad3, SMA and collagen I and III (P<0.05), but not Smad7 (P>0.05). Knockdown of Smad2 and Smad3 inhibited proliferation and migration of AFs and down-regulated the expression of SMA and collagen I and III (P<0.05). TGF-ß1 plays a key role in remodeling processes by contributing to the proliferation, migration and phenotypic modulation of AFs and collagen composition. The mechanism may be related to both the Smad2 and Smad3 signaling pathways.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	3
Volume Number	4
Language	English
Publisher	Spandidos Publications
Publisher Date	2011-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Fibroblasts Drug Effects Metabolism Smad2 Protein Smad3 Protein Transforming Growth Factor Beta1 Pharmacology Animals Blotting, Western Cell Movement Cell Proliferation Cell Transdifferentiation Extracellular Matrix Cytology Gene Expression Regulation Gene Knockdown Techniques Rna, Messenger Genetics Rna, Small Interfering Reverse Transcriptase Polymerase Chain Reaction Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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