NDLI: Cyclooxygenase mediates cardioprotection of angiotensin-(1-7) against ischemia/reperfusion-induced injury through the inhibition of oxidative stress.

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Cyclooxygenase mediates cardioprotection of angiotensin-(1-7) against ischemia/reperfusion-induced injury through the inhibition of oxidative stress.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liao, Xinxue Lan, Aiping Yang, Zhanli He, Jiangui Wang, Huaqiao Ma, Hong Yang, Chuntao Feng, Jianqiang Wang, Lichun Wang, Xiuyu Guo, Ruixian Dong, Xiaobian
Description	Author Affiliation: Liao X ( Department of Cardiovasology, Hypertension and Vascular Diseases, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, PR China.)
Abstract	Angiotensin (Ang)-(1-7) exhibits cardioprotective effects in myocardial ischemia reperfusion (I/\|R)-induced injury. However, the roles of oxidation and cyclooxygenase (COX) in the cardioprotection of Ang-(1-7) remain unclear. This study was conducted to investigate whether oxidation and COX were involved in the cardioprotection of Ang-(1-7) against I/\|R-induced injury in isolated rat hearts. The hearts were subjected to 15 min regional ischemia followed by 30 min reperfusion. Myocardial I/\|R treatment induced significant cardiac dysfunction, including ventricular arrhythmia (VA) and a reduction of left ventricular systolic pressure (LVSP), cardiomyocyte apoptosis and oxidative stress, manifesting as an increase in malondialdehyde (MDA) production and a decrease in superoxide dismutase (SOD) activity. Pretreatment of the hearts with 1.0 nmol/\|l Ang-(1-7) for 30 min prior to ischemia considerably attenuated I/\|R-induced VA, apoptosis and MDA production, and enhanced LVSP and SOD activity. These cardioprotective effects of Ang-(1-7) were antagonized by the intraperitoneal injection of 5 mg/\|kg body weight indomethacin (IDM, a COX inhibitor), presenting as an enhancement of VA, apoptosis and MDA production as well as a reduction of LVSP and SOD activity. In conclusion, COX mediated Ang-(1-7)-induced cardioprotection via its antioxidative mechanism.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	4
Language	English
Publisher	Spandidos Publications
Publisher Date	2011-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Angiotensin I Pharmacology Cardiotonic Agents Myocardial Reperfusion Injury Prevention & Control Oxidative Stress Drug Effects Peptide Fragments Prostaglandin-endoperoxide Synthases Metabolism Animals Apoptosis Arrhythmias, Cardiac Blood Pressure Physiology Cyclooxygenase Inhibitors Indomethacin Malondialdehyde Superoxide Dismutase Ventricular Function Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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