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Macrolides for the treatment of chronic bacterial prostatitis: an effective application of their unique pharmacokinetic and pharmacodynamic profile (Review).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Parnham, M. J. Skerk, V. Mazzoli, S. Markotic, A. Perletti, G. Wagenlehner, F. M. E. Naber, K. G. Magri, V.
Description	Country affiliation: Italy Author Affiliation: Perletti G ( Department of Biomedical, Inf., Comm. and Env. Sciences, University of Insubria, Busto A, I-21052 Varese, Italy. gianpaolo.perletti@uninsubria.it)
Abstract	Chronic bacterial prostatitis (CBP) is a persistent infection of the prostate characterized by poor quality of life mainly due to frequent relapse episodes caused by incomplete eradication of causative pathogens. Aggressive antibacterial therapy is required to attenuate the severe symptoms of CBP and to achieve a permanent cure. Although fluoroquinolones are currently recommended as first-choice agents, macrolide antibiotics are emerging as a noteworthy option for the treatment of CBP. Macrolide antibiotics are characterized by an impressive array of distinct pharmacokinetic (PK) and pharmacodynamic (PD) properties. These properties include high intracellular accumulation in phagocytes and at sites of infection, including the prostate; broad antibiotic but also biofilm-inhibiting properties; immunomodulating and inflammation-resolving activities. These features offer particular advantages for the treatment of chronic infections of the prostate gland, which are not easily amenable to drug therapy. Macrolides may be exploited to counteract the unsatisfactory rates of clinical symptom improvement and pathogen eradication. The results of a number of clinical trials support this proposal.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	4
Language	English
Publisher	Spandidos Publications
Publisher Date	2011-11-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Anti-bacterial Agents Therapeutic Use Fluoroquinolones Pharmacokinetics Macrolides Prostatitis Drug Therapy Biofilms Drug Effects Clinical Trials As Topic Drug Resistance, Bacterial Gram-negative Bacteria Physiology Gram-positive Bacteria Pathology Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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