NDLI: Arazyme inhibits cytokine expression and upregulates skin barrier protein expression.

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Arazyme inhibits cytokine expression and upregulates skin barrier protein expression.

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Arazyme inhibits cytokine expression and upregulates skin barrier protein expression.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kim, In Sik Lee, Ji-Sook Kim, Mi Jin Park, Ho-Yong Shin, Dong-Ha Son, Kwang-Hee
Description	Author Affiliation: Kim IS ( Department of Biomedical Laboratory Science, School of Medicine, Eulji University, Daejeon, Chungnam 301746, Republic of Korea.)
Abstract	In the present study, the inhibitory effect of arazyme on allergic inflammation was investigated by evaluating the alteration of cytokine production and expression of skin barrier proteins in immune and HaCaT human keratinocyte cells. THP1 human monocytic and EoL1 human eosinophilic cells were treated with Dermatophagoides pteronissinus extract (DpE). Monocyte chemotactic protein1 (MCP1)/CCL2, interleukin (IL)6 and IL8 increased following DpE treatment and arazyme significantly blocked the increase of MCP1, IL6 and IL8 expression in cell types. Secretion of MCP1, IL6 and IL8 induced by lipopolysaccharide in THP1 cells was also inhibited by arazyme treatment. Arazyme inhibited the secretion of IL6 and IL8 due to phorbol 12myristate 13acetate and calcium ionophores in human mast cells. Arazyme blocked the secretion of thymus and activationregulated chemokine (TARC)/CCL17, MCP1, IL6 and IL8 due to tumor necrosis factor (TNF ) and interferonÎ³ (IFNÎ³) in HaCaT cells. TNF and IFNÎ³ suppressed the expression of skin barrier proteins, including filaggrin, involucrin and loricrin. By contrast, arazyme increased the expression of filaggrin, involucrin and loricrin. These results may contribute to the development of a therapeutic drug for the treatment of allergic diseases, including atopic dermatitis.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	8
Language	English
Publisher	Spandidos Publications
Publisher Date	2013-08-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Bacterial Proteins Pharmacology Cytokines Metabolism Metalloproteases Skin Drug Effects Isolation & Purification Cell Line Chemokine Ccl2 Biosynthesis Genetics Enterobacteriaceae Eosinophils Pathology Gene Expression Regulation Interleukin-8 Intermediate Filament Proteins Keratinocytes Membrane Proteins Monocytes Immunology Protein Precursors Up-regulation Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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