NDLI: MiR203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin.

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MiR203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xu, Lijian Xu, Dong An, Yong Wang, Qingguang
Description	Author Affiliation: Xu D ( Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210018, P.R. China.)
Abstract	MicroRNAs have emerged as crucial regulators of tumorigenesis. However, the mechanism by which miR203 is involved in the pathogenesis of pancreatic cancer (PC) remains elusive. In the present study, PC cell lines were used as an experimental model to investigate the expression and functional role of miR203 in PC. miR203 mimic virus, miRNA negative control virus and Survivin shRNA virus were transfected into the PC cell line, CFPAC1. mRNA and protein levels of Survivin were detected using qPCR and western blot analysis. Proliferation, apoptosis and cell cycle profiles were detected by an MTT assay and flow cytometry. Female BALB/cAnu nude mice were used to validate the role of miR203 in vivo. The protein levels of Survivin were found to negatively correlate with miR203 levels in four PC cell lines. A luciferase assay revealed that Survivin was a direct target of miR203. Transfection with miR203 mimic inhibited CFPAC1 cell proliferation and induced apoptosis and G1 phase cell cycle arrest, similar to knockdown of Survivin. In the in vivo nude mouse model, the downregulation of Survivin by knockdown of Survivin or transfection with miR203 mimic inhibited tumor growth. Results of the current study indicate that miR203 regulates the proliferation, apoptosis and cell cycle progression of PC cells by targeting Survivin.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	2
Volume Number	8
Language	English
Publisher	Spandidos Publications
Publisher Date	2013-08-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Apoptosis Genetics Cell Cycle Inhibitor Of Apoptosis Proteins Micrornas Pancreatic Neoplasms Animals Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Metabolism Mice Pathology Rna Interference Tumor Burden Xenograft Model Antitumor Assays Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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