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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ohtsubo, M. Roberts, J. M. Assoian, R. K. Böhmer, R. M. Zhu, X. |
| Description | Author Affiliation: Zhu X ( Department of Cell Biology and Anatomy, University of Miami School of Medicine, FL 33101, USA.) |
| Abstract | Growth factors and cell anchorage jointly regulate transit through G1 in almost all cell types, but the cell cycle basis for this combined requirement remains largely uncharacterized. We show here that cell adhesion and growth factors jointly regulate the cyclin D1- and E- dependent kinases. Adhesion to substratum regulates both the induction and translation of cyclin D1 mRNA. Nonadherent cells fail to phosphorylate the retinoblastoma protein (Rb), and enforced expression of cyclin D1 rescues Rb phosphorylation and entry into S phase when G1 cells are cultured in the absence of substratum. Nonadherent cells also fail to activate the cyclin E-associated kinase, and this effect can be linked to an increased association of the cdk inhibitors, p21 and p27. These data describe a striking convergence in the cell cycle controls used by the two major signal transduction systems responsible for normal and abnormal cell growth. Taken together with our previous studies showing adhesion-dependent expression of cyclin A, they also establish the cell cycle basis for explaining the combined requirement for growth factors and the extracellular matrix in transit through the Rb checkpoint, entry into S phase, and anchorage-dependent growth. |
| ISSN | 00219525 |
| e-ISSN | 15408140 |
| Journal | The Journal of Cell Biology |
| Issue Number | 2 |
| Volume Number | 133 |
| Language | English |
| Publisher | Rockefeller University Press (United States) |
| Publisher Date | 1996-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | CDC2-CDC28 Kinases Cell Cycle Proteins Cell Cycle Physiology Cyclin-Dependent Kinases Metabolism Cyclins Biosynthesis Oncogene Proteins Protein-Serine-Threonine Kinases Retinoblastoma Protein Tumor Suppressor Proteins 3T3 Cells Animals Cell Adhesion Cyclin D1 Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase Inhibitor P21 Cyclin-Dependent Kinase Inhibitor P27 Antagonists & Inhibitors Genetics Cycloheximide Pharmacology Enzyme Inhibitors Fibroblasts Cytology Gene Expression Mice Microtubule-Associated Proteins Mitogens Phosphorylation Protein Synthesis Inhibitors Proteins RNA, Messenger Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine |
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