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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Malmsten, Martin Bysell, Helena Hansson, Per |
| Description | Country affiliation: Sweden Author Affiliation: Bysell H ( Department of Pharmacy, Uppsala University, P.O. Box 580, SE-751 23 Uppsala, Sweden. helena.bysell@farmaci.uu.se) |
| Abstract | The interaction between poly-L-lysine (pLys) and oppositely charged poly(acrylic acid) (pAA) microgels (Ø approximately 80-120 microm) was studied by micromanipulator-assisted light microscopy and confocal laser scanning microscopy. The aim of this study was to investigate effects of peptide size, pH, and salt concentration on binding, transport, and distribution of pLys in pAA microgel particles and thereby also to outline the details of the gel deswelling in response to pLys binding and incorporation. Both peptide distribution and gel deswelling kinetics were found to be strongly influenced by the pLys molecular weight, originating partly from limited entry of large peptides into the gel particle core. Also pH was shown to influence both deswelling and pLys incorporation kinetics, with a decreased deswelling rate observed with increasing pH. These effects are determined by a complex interplay between the pH-dependence of both pLys and the gel network, also influencing volume transitions of the latter. Finally, salt concentration was shown to have a significant effect on both gel deswelling rate and pLys transport, with an increased electrolyte concentration resulting in decreased deswelling rate but also in an increased peptide transport rate within the microgel particles. |
| ISSN | 00219797 |
| Issue Number | 1 |
| Volume Number | 323 |
| e-ISSN | 10957103 |
| Journal | Journal of Colloid and Interface Science |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-07-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Acrylic Resins Chemistry Biochemistry Methods Gels Polylysine Metabolism Hydrazines Pharmacology Hydrogen-ion Concentration Kinetics Lysine Materials Testing Microscopy, Confocal Peptides Salts Temperature Time Factors Journal Article Research Support, Non-u.s. Gov't Discipline Colloid & Interface Science |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surfaces, Coatings and Films Colloid and Surface Chemistry Biomaterials Electronic, Optical and Magnetic Materials |
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