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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vallejo, M. García, A. Barbas, C. Angulo, S. García-Martínez, D. |
| Description | Country affiliation: Spain Author Affiliation: Vallejo M ( Facultad de Farmacia, Universidad San Pablo-CEU Madrid, Campus Monteprincipe, Boadilla del Monte 28668, Madrid, Spain.) |
| Abstract | Benefits of capillary electrophoresis to provide a comprehensive snapshot of multiple metabolites in biological samples have been exploited. Afterwards, multivariate statistical methods can be employed in order to mine additional information from the data. Urine fingerprints of control and diabetic rats have shown the clear effects of an antioxidant treatment on diabetic animals, which were not seen in controls, in a rapid, simple and cost-effective way without identifying a single marker. The procedure involves the measurement of samples with a relatively inexpensive tool such as CE-UV, without any previous treatment other than filtration and the application of chemometric tools [PCA (principal components analysis) and PLS-DA (partial least squares discriminant analysis)]. Data pre-treatment of electrophoretic profiles (alignment, normalization and baseline correction) has shown to be key for further chemometric treatment. Once developed, the methodology can easily be applied for a rapid in vivo screening of extracts with potential in vitro activity. Classification was supported by that produced after PCA and PLS-DA of target variables obtained with selectively designed, time and reagent consuming methods. |
| ISSN | 00219673 |
| Issue Number | 1-2 |
| Volume Number | 1187 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-04-11 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Antioxidants Therapeutic Use Ascorbic Acid Chromatography, Micellar Electrokinetic Capillary Methods Diabetes Mellitus, Experimental Drug Therapy Urine Vitamin E Animals Biochemistry Drug Combinations Electrophoresis, Capillary Glutathione Metabolism Glutathione Disulfide Liver Male Rats Rats, Sprague-dawley Comparative Study Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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