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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dai, Lulu Zhang, Kelly Wigman, Larry |
| Description | Country affiliation: United States Author Affiliation: Dai L ( Genentech Inc, Small Molecule Pharmaceutical Science, 1 DNA Way, South San Francisco, CA 94080, USA.); Wigman L ( Genentech Inc, Small Molecule Pharmaceutical Science, 1 DNA Way, South San Francisco, CA 94080, USA.); Zhang K ( Genentech Inc, Small Molecule Pharmaceutical Science, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: zhang.kelly@gene.com.) |
| Abstract | A sensitive analytical method using mixed mode HPLC separation coupled with charged aerosol detection (CAD) was developed for quantitative analysis of lithium. The method is capable of separating lithium ion from different drug matrices and other ions in a single run thus eliminating the organic matrix and ionic analyte interferences without extensive sample preparation such as derivatization and extraction. The separation space and chromatographic conditions are defined by systematic studies of the retention behaviors of lithium and potential interfering ions and different type of pharmaceutical APIs (active pharmaceutical ingredients) under reversed-phase, HILIC and cation/anion exchange mechanisms. Compared to other current analytical techniques for lithium analysis, the presented method provides a new approach and demonstrates high sensitivity (0.02ng for LOD and 0.08ng for LOQ in both standard and sample solution). The method has been validated for pharmaceutical samples and can be potentially applied to biological, food and environmental samples. |
| ISSN | 00219673 |
| Volume Number | 1408 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-21 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Lithium Compounds Analysis Aerosols Chromatography, High Pressure Liquid Chromatography, Ion Exchange Chromatography, Reverse-phase Hydrogen-ion Concentration Osmolar Concentration Sensitivity And Specificity Journal Article Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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