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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Armstrong, Daniel W. Deáková, Zuzana Duracková, Zdenka Lehotay, Jozef |
| Description | Author Affiliation: Deáková Z ( Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia); Duracková Z ( Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 811 08 Bratislava, Slovakia.); Armstrong DW ( Department of Chemistry and Biochemistry, University of Texas at Arlington, 700 Planetarium Place, Arlington, TX 76019, USA.); Lehotay J ( Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia. Electronic address: jozef.lehotay@stuba.sk.) |
| Abstract | A two-dimensional HPLC system with electrochemical detection was used for determination of homocysteine, methionine and cysteine enantiomers in biological samples. The amino acid separations were not possible only by using a chiral column. The compounds were separated from each other on an achiral column (Purospher RP-18 endcapped 250-4mm, 5µm) and their enantiomers were separated on Chirobiotic TAG (250-4.6mm, 5µm) column in an on-line system. The mobile phase composition and a choice of electrode potentials for detection were investigated. The l-enantiomers always eluted before the d-enantiomers. The proposed method was applied to the analysis of human serum of healthy volunteers and patients with multiple sclerosis. The limit of detection (LOD) and quantitation (LOQ) were defined as the concentration that produced a signal-to-noise ratio (S/N) of 3 and 10. The method LOD values were found to be between 0.05 and 0.50µgmL(-1). The range of LOQ values were between 0.17 and 1.67µgmL(-1), respectively. |
| ISSN | 00219673 |
| Volume Number | 1408 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-21 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cysteine Blood Homocysteine Methionine Adult Case-control Studies Chromatography, High Pressure Liquid Chemistry Female Humans Limit Of Detection Male Multiple Sclerosis Cerebrospinal Fluid Signal-to-noise Ratio Stereoisomerism Young Adult Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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