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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kawano, Shin-ichi Yu, Dianbao Liu, Jiaqi Hashi, Yuki Shen, Lingling Zhan, Song Liu, Zhaofeng Huang, Taohong Li, Siming Yao, Jinting Zhong, Qisheng Zhou, Ting |
| Description | Country affiliation: China Author Affiliation: Zhong Q ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Shen L ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Liu J ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Yu D ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Li S ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Yao J ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Zhan S ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Huang T ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Hashi Y ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Kawano S ( Shimadzu Global COE for Application & Technical Development, Guangzhou 510010, China.); Liu Z ( Guangdong Institute for Food and Drug Control, Guangzhou 510180, China.); Zhou T ( School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China) |
| Abstract | Pre-column dilution large volume injection (PD-LVI), a novel sample injection technique for reverse phase ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), was developed in this study. The PD-LVI UHPLC-MS/MS system was designed by slightly modifying the commercial UHPLC-MS/MS equipment with a mixer chamber. During the procedure of PD-LVI, sample solution of 200µL was directly carried by the organic mobile phase to the mixer and diluted with the aqueous mobile phase. After the mixture was introduced to the UHPLC column in a mobile phase of acetonitrile-water (15/85, v/v), the target analytes were stacked on the head of the column until following separation. Using QuEChERS extraction, no additional steps such as solvent evaporation or residue redissolution were needed before injection. The features of PD-LVI UHPLC-MS/MS system were systematically investigated, including the injection volume, the mixer volume, the precondition time and the gradient elution. The efficiency of this approach was demonstrated by direct analysis of 24 pesticides in cabbages. Under the optimized conditions, low limits of detection (0.00074-0.8 ng/kg) were obtained. The recoveries were in the range of 63.3-109% with relative standard deviations less than 8.1%. Compared with common UHPLC-MS/MS technique, PD-LVI UHPLC-MS/MS showed significant advantages such as excellent sensitivity and reliability. The mechanism of PD-LVI was demonstrated to be based on the column-head stacking effect with pre-column dilution. Based on the results, PD-LVI as a simple and effective sample injection technique of reverse phase UHPLC-MS/MS for the analysis of trace analytes in complex samples showed a great promising prospect. |
| ISSN | 00219673 |
| Volume Number | 1442 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Brassica Chemistry Chromatography, High Pressure Liquid Food Analysis Methods Pesticides Analysis Tandem Mass Spectrometry Instrumentation Reproducibility Of Results Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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