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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shpigun, O. A. Rodin, I. A. Stavrianidi, A. N. Rybalchenko, I. V. Lebedev, A. T. Braun, A. V. Baygildiev, T. M. |
| Description | Author Affiliation: Baygildiev TM ( Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia. Electronic address: timurbaychem@gmail.com.); Rodin IA ( Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.); Stavrianidi AN ( Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia); Braun AV ( Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia); Lebedev AT ( Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.); Rybalchenko IV ( Kostroma State Technological University, 156005 Kostroma, Russia.); Shpigun OA ( Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.) |
| Abstract | Once exposed to the environment organophosphate nerve agents readily degrade by rapid hydrolysis to the corresponding alkyl methylphosphonic acids which do not exist in nature. These alkyl methylphosphonic acids are finally slowly hydrolyzed to methylphosphonic acid. Methylphosphonic acid is the most stable hydrolysis product of organophosphate nerve agents, persisting in environment for a long time. A highly sensitive method of methylphosphonic acid and alkyl methylphosphonic acids detection in dust and ground mixed samples has been developed and validated. The fact that alkyl methylphosphonic acids unlike methylphosphonic acid did not react with p-bromophenacyl bromide under chosen conditions was discovered. This allowed simultaneous chromatographic separation and mass spectrometric detection of derivatized methylphosphonic acid and underivatized alkyl methylphosphonic acids using HILIC-MS/MS method. Very simple sample pretreatment with high recoveries for each analyte was developed. Methylphosphonic acid pre-column derivate and alkyl methylphosphonic acids were detected using tandem mass spectrometry with electrospray ionization after hydrophilic interaction liquid chromatography separation. The developed approach allows achieving ultra-low detection limits: 200 pg mL(-1) for methylphosphonic acid, 70 pg mL(-1) for ethyl methylphosphonic acid, 8 pg mL(-1) for i-propyl methylphosphonic acid, 8 pg mL(-1) for i-butyl methylphosphonic acid, 5 pg mL(-1) for pinacolyl methylphosphonic acid in the extracts of dust and ground mixed samples. This approach was successfully applied to the dust and ground mixed samples from decommissioned plant for the production of chemical weapons. |
| ISSN | 00219673 |
| Volume Number | 1442 |
| e-ISSN | 18733778 |
| Journal | Journal of Chromatography A |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-15 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Acetophenones Chemistry Chromatography, Liquid Environmental Monitoring Methods Organophosphorus Compounds Analysis Tandem Mass Spectrometry Hydrolysis Hydrophobic And Hydrophilic Interactions Organophosphonates Soman Analogs & Derivatives Water Pollutants, Chemical Journal Article Research Support, Non-u.s. Gov't Discipline Analytical Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Analytical Chemistry Biochemistry |
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