NDLI: Dose Dependent Hepatic and Endothelial Changes in Rats Treated with Dexamethasone.

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Dose Dependent Hepatic and Endothelial Changes in Rats Treated with Dexamethasone.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kumar, V. Hemanth Narendar, K. Yendigeri, Saeed M. Ch, Rajasekhar Im, Nagendra Nayak Huilgol, Shobha V.
Description	Country affiliation: India Author Affiliation: Kumar VH ( Lecturer, Department of Pharmacology, Al-Ameen Medical College , Bijapur, Karnataka, India .); Im NN ( Professor, Department of Pharmacology, K.S. Hegde Medical Academy, NITTE University , Mangalore, Karnataka, India .); Huilgol SV ( Professor, Department of Pharmacology, Al-Ameen Medical College , Bijapur, Karnataka, India .); Yendigeri SM ( Associate Professor, Department of Pathology, Al-Ameen Medical College , Bijapur, Karnataka, India .); K N ( Lecturer, Department of Pharmacology, Al-Ameen Medical College , Bijapur, Karnataka, India .); Ch R ( Tutor, Department of Pharmacology, KVG Medical College , Sullia, Karnataka, India .)
Abstract	AIMS AND OBJECTIVES: To study the effect of dexamethasone on liver and endothelium, and to determine the optimum dose which induces the abnormal changes in liver and endothelium in Wistar rats. MATERIALS AND METHODS: Albino Wistar rats were divided into 7 groups (n=6). Control group rats received normal saline. Graded doses of dexamethasone (0.5,1,2,4,8 and 16mg/kg/ i.p.) was administered to the groups for six days. Liver and aorta were dissected at the end of the study and examined for histopathological changes under microscope. RESULTS: Intraperitoneal administration of dexamethasone (4,8 and 16mg/kg) for six days resulted in fatty changes in liver and same doses have shown thickening of endothelial layers in aorta, in comparison to control group. There were not much significant changes seen in low doses of dexamethasone (0.5, 1 and 2mg/kg). CONCLUSION: It is concluded that the acute high doses of dexamethasone (4,8 and 16mg/kg) for six days caused hepatic steatosis and showed mild to moderate arteriosclerosis in aorta. These changes may be secondary consequences of insulin resistance. Hence, it can be used as new animal model to screen the various plants and medicines in the treatment of insulin resistance.
ISSN	2249782X
e-ISSN	0973709X
DOI	10.7860/JCDR/2015/12810.5930
Journal	JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Issue Number	5
Volume Number	9
Language	English
Publisher	Dr. Hemant Jain (for Premchand Shantidevi Research Foundation)
Publisher Date	2015-05-01
Publisher Place	India
Access Restriction	Open
Subject Keyword	Discipline Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry

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