NDLI: Glaucoma Detection Ability of Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Preperimetric Glaucoma.

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Glaucoma Detection Ability of Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Preperimetric Glaucoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seol, Bo Ram Park, Ki Ho Jeoung, Jin Wook
Abstract	PURPOSE: We evaluated the glaucoma detection ability of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) and compared it to peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters in myopic preperimetric glaucoma (PPG). METHODS: We analyzed 353 eyes, including 67 nonmyopic preperimetric glaucomatous eyes, 182 myopic healthy eyes, and 104 myopic preperimetric glaucomatous eyes. Myopic PPG detection abilities of the respective parameters were assessed by calculating the area under receiver operating characteristic (AUROC) curves. The myopic eyes were divided into two groups (a nonhighly myopic and a highly myopic group). The diagnostic performance was analyzed for each group independently, and differences between the two groups also were evaluated. RESULTS: The best parameter for discrimination of myopic PPG from myopic healthy eyes was inferotemporal macular GCIPL thickness. The AUROCs of this parameter were 0.752, 0.747, and 0.737 in the total myopic, nonhighly myopic, and highly myopic groups, respectively. These were significantly larger than the AUROCs of the other parameters, including average RNFL thickness, average GCIPL thickness, rim area, inferior RNFL thickness, and minimum GCIPL thickness (P = 0.021, 0.012, 0.016, 0.036, and 0.013, respectively). The inferotemporal macular GCIPL thickness showed no significant difference between nonhighly myopic and highly myopic groups. CONCLUSIONS: The inferotemporal macular GCIPL thickness was the best PPG-detection parameter for myopic eyes. Inferotemporal macular GCIPL thickness evaluation can be considered to be a useful means of diagnosing PPG in myopic eyes.
ISSN	01460404
e-ISSN	15525783
Journal	Investigative Opthalmology & Visual Science
Issue Number	13
Volume Number	56
Language	English
Publisher	Association for Research in Vision and Ophthalmology
Publisher Date	2015-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Glaucoma Diagnosis Intraocular Pressure Myopia Optic Disk Pathology Retinal Ganglion Cells Tomography, Optical Coherence Visual Fields Cross-sectional Studies Complications Physiopathology Nerve Fibers Roc Curve Retrospective Studies Discipline Ophthalmology
Content Type	Text
Resource Type	Article
Subject	Ophthalmology Sensory Systems Cellular and Molecular Neuroscience

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